Abstract
The composition of 15 V Tβ gene subfamilies has been examined by Southern hybridization among a broad spectrum of colony bred rat and mouse species extending phylogenetically from Rattus to Mus musculus domesticus. Most mouse species contain a similar content of V Tβ genes as determined by the number of hybridizing restriction fragment (RF) bands. Furthermore, the extent of restriction fragment length polymorphism (RFLP) appears to be limited. Some V Tβ gene families, however, are missing from Rattus (VTβ7, V Tβ12) and M. shortridgei (V Tβ9, V Tβ16). Extension of the V Tβ survey to a panel of 38 wild-caught mice reveals that nearly a third lack specific hybridization to the V Tβ5 probe. Previous reports have established that the mouse inbred strains SJL, C57BR, C57L, and SWR lack 50% of their V Tβ repertoire, including V Tβ5 (Behlke et al. 1985). This study demonstrates that natural populations of mice also carry a significantly reduced V Tβ gene repertoire.
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Huppi, K.E., D'Hoostelaere, L.A., Mock, B.A. et al. T-cell receptor V Tβ genes in natural populations of mice. Immunogenetics 27, 51–56 (1988). https://doi.org/10.1007/BF00404444
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DOI: https://doi.org/10.1007/BF00404444