Skip to main content
Log in

Antigenic polymorphism of a serum protein migrating electrophoretically in the a region detected by using a strain derived from the Japanese wild mouse (Mus musculus molossinus)

  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

Antigenic specificities of a serum protein from the mouse Mol-A strain (a strain derived from the Japanese wild mouse, Mus musculus molossinus) was studied by gel precipitation with alloantisera produced by reciprocal alloimmunization between Mol-A and BALB/c mice. Alloantigens which migrate immunoelectrophoretically in the a region of serum proteins have also been identified. The evidence indicated that this antigenic specificity is controlled by a codominant autosomal locus designated Aph-1. The evidence also suggests that the Aph-1 locus is linked to the a locus on chromosome 2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Cinader, B., Dubiski, S., and Wardlaw, A. C.: Distribution, inheritance, and properties of an antigen, MuB1, and its relation to hemolytic complement. J. Exp. Med. 120: 897–924, 1964

    Google Scholar 

  • Hayakawa, J., Nikaido, H., and Koizumi, T.: Genetic polymorphism of the sixth component of complement (C6) in mice. Immunogenetics 20: 633–638, 1984

    Google Scholar 

  • Herzenberg, L. A., Tachibana, D. K., Herzenberg, L. A., and Rosenberg, L. T.: A gene locus concerned with hemolytic complement in Mus musculus. Genetics 48: 711–715, 1963

    Google Scholar 

  • Klein, J.: The mouse and its forms. In: Biology of the Mouse Histocompatibility-2 Complex, pp. 16–39, Springer-Verlag, New York, Heidelberg, Berlin, 1975

    Google Scholar 

  • Kurihara, Y., Miyashita, N., Moriwaki, K., Petras, M. L., Bonhomme, F., Cho, W. S., and Kohno, S.: Serological survey of T-lymphocyte differentiation antigens in wild mice. Immunogenetics 22: 211–218, 1985

    Google Scholar 

  • Lieberman, R. and Potter, M.: Crossing over between genes in the immunoglobulin heavy chain linkage group of the mouse. J. Exp. Med. 30: 519–541, 1969

    Google Scholar 

  • Marshall, Jr., J. T.: A synopsis of Asian species of Mus (Rodentia, Muridae). Bull. Am. Mus. Nat. Hist. 158: 175–220, 1977

    Google Scholar 

  • Moriwaki, K., Shiroishi, T., Minezawa, M., Aotsuka, T., and Kondo, K.: Frequency distribution of histocompatibility-2 antigenic specificities in the Japanese wild mouse genetically remote from the European subspecies. J. Immunogenet. 6: 97–113, 1979

    Google Scholar 

  • Natsuume-Sakai, S., Moriwaki, K., Amsno, S., Hayakawa, J., Kaido, T., and Takahashi, M.: Allotypes of C3 in the laboratory and wild mouse distinguished by alloantisera. J. Immunol. 123: 216–221, 1979

    Google Scholar 

  • Natsuume-Sakai, S., Moriwaki, K., Migita, S., Sudo, K., Suzuki, K., Lu, D.-Y., Wang, C., and Takahashi, M.: Structural polymorphism of murine factor B controlled by a locus closely linked to the H-2 complex and demonstration of multiple alleles. Immunogenetics 18: 117–124, 1983

    Google Scholar 

  • Natsuume-Sakai, S., Sudo, K., Kaido, T., Hayakawa, J., and Takahashi, M.: Structural polymorphism of murine complement factor H controlled by a locus located between the He and the β2m locus on the second chromosome of the mouse. J. Immunol. 134: 2600–2606, 1985

    Google Scholar 

  • Nomura, T., Esaki, K., and Tomita, T. (eds.): II. Qualitative characters in genetic monitoring. In ICLAS Manual for Genetic Monitoring of Inbred Mice, pp. 23–110, University of Tokyo Press, Tokyo, 1984

    Google Scholar 

  • Schwarz, E. and Schwarz, H. K.: The wild and commensal stocks of the house mouse, Mus musculus Linnaeus. J. Mammal. 24: 59–72, 1943

    Google Scholar 

  • Takahashi, S., Fukuoka, Y., Moriwaki, K., Okuda, T., Tachibana, T., Natsuume-Sakai, S., and Takahashi, M.: Structural polymorphism of mouse complement C2 detected by microscale peptide mapping: Linkage to H-2. Immunogenetics 19: 493–501, 1984

    Google Scholar 

  • Tiselius, A. and Kabat, E. A.: An electrophoretic study of immune sera and purified antibody preparations. J. Exp. Med. 69: 119–131, 1939

    Google Scholar 

  • Watanabe, T., Ito, T., and Ogasawara, N.: Biochemical markers of three strains derived from Japanese wild mouse (Mus musculus molossinus). Biochem. Genet. 20: 385–393, 1982

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harada, Yn., Hayakawa, Ji. & Tomita, T. Antigenic polymorphism of a serum protein migrating electrophoretically in the a region detected by using a strain derived from the Japanese wild mouse (Mus musculus molossinus). Immunogenetics 24, 47–50 (1986). https://doi.org/10.1007/BF00372297

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00372297

Keywords

Navigation