Skip to main content
Log in

The gene encoding the Ia-Associated invariant chain is located on chromosome 18 in the mouse

  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (la) was determined by Southern blot analysis of DNA from a panel of mouse x Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse Ii cDNA as a hybridization probe, we localized the gene coding for the invariant chain to mouse chromosome 18.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ballard, P. L.: Glucocorticoids and differentiation. In J. D. Baxter and G. G. Rousseau (eds.): Glucocorticoid Hormone Action, pp. 493–475, Springer Verlag, Berlin, Heidelberg, New York, 1979

    Google Scholar 

  • Claesson, L., Larhammer, D., Rask, L., and Peterson, P. A.: cDNA clone for the human invariant chain of class II histocompatibility antigens and its implications for the protein structure. Proc. Natl. Acad. Sci. U.S.A. 80: 7395–7399, 1983

    Google Scholar 

  • Claesson-Welsh, L., Barker, P. E., Larhammar, D., Rask, L., Ruddle, F. H., and Peterson, P. A.: The gene encoding the human class II antigen-associated y chain is located on chromosome 5. Immunogenetics 20: 89–93, 1984

    Google Scholar 

  • Collins, T., Korman, A. J., Wake, C. T., Boss, J. M., Kappes, D. J., Fiers, W., Ault, K. A.., Gimbrone, M. A., Strominger, J. L., and Pober, J. S.: Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endolethial cells and dermal fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 81: 4917–4921, 1984

    Google Scholar 

  • Day, C. E. and Jones, P. P.: The gene encoding the la antigen-associated invariant chain (Ii) is not linked to the H-2 complex. Nature 302: 157–159, 1983

    Google Scholar 

  • Dretzen, G., Bellard, A., Sassone-Corsi, P., and Chambon, P.: A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal. Biochem. 112: 295–298, 1981

    Google Scholar 

  • Feinberg, A. P. and Vogelstein, B.: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132: 6–13, 1983

    Google Scholar 

  • Francke, U. and Gehring, U.: Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intra species somatic cell hybrids. Cell 22: 657–664, 1980

    Google Scholar 

  • Francke, U. and Taggart, R. T.: Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse. Proc. Natl. Acad. Sci. U.S.A. 76: 5230–5233, 1979

    Google Scholar 

  • Francke, U., Lalley, P. A., Moss, W., Ivy, I., and Minna, J. D.: Gene mapping in Mus musculus by interspecific cell hybridization. Cytogenet. Cell Genet. 19: 57–84, 1977

    Google Scholar 

  • Gehring, U., Segnitz, B., Foellmer, B., and Francke, U.: Chromosome assignment of the human gene for the glucocorticoid receptor (GRL). Cytogenet. Cell Genet. 37: 476, 1984

    Google Scholar 

  • Hämmerling, G. J.: Tissue distribution of la antigens and their expression on lymphocyte subpopulations. Transplant. Rev. 30: 64–82, 1976

    Google Scholar 

  • Jones, P. P., Murphy, D. B., Hewgill, D., and McDevitt, H. O.: Detection of a common polypeptide chain in I-A and I-E subregion immunoprecipitates. Immunochemistry 16: 51–60, 1978

    Google Scholar 

  • Klein, J. and Nagy, Z. A.: MHC restriction and Ir genes. Adv. Cancer Res. 37: 233–317, 1982

    Google Scholar 

  • Koch, N. and Harris, A. W.: Differential expression of the invariant chain in mouse tumor cells: Relationship to B lymphocyte development. J. Immunol. 132: 12–15, 1984

    Google Scholar 

  • Koch, N., Hämmerling, G. J., Szymura, J., and Wabl, M. R.: Ia associated Ii chain is not encoded by chromosome 17 of the mouse. Immunogenetics 16: 603–606, 1982

    Google Scholar 

  • Koch, N., Wong, G. H. W., and Schrader, J. W.: Ia antigens and associated invariant chain are induced simultaneously in lines of T-dependent mast cells by recombinant interferon-γ. J. Immunol. 132: 1361–1369, 1984

    Google Scholar 

  • Kvist, S., Wiman, K., Claesson, L., Peterson, P. A., and Dobberstein, B.: Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell 29: 61–69, 1982

    Google Scholar 

  • Schäfer, R., Doehmer, J., Drüge, P. M., Rademacher, I., and Willecke, K.: Genetic analysis of transformed and malignant phenotypes in somatic cell hybrids between tumorigenic Chinese hamster cells and diploid mouse fibroblasts. Cancer Res. 41: 1214–1221, 1981

    Google Scholar 

  • Singer, P., Lauer, W., Dembić, Z., Meyer, W., Lipp, J., Koch, N., Hämmerling, G., Klein, J., and Dobberstein, B.: Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone. EMBO J. 3: 873–877, 1984

    Google Scholar 

  • Southern, E.: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 503–517, 1975

    Google Scholar 

  • Steinmetz, M. and Hood, L.: Gene of the major histocompatibility complex in mouse and man. Science 222: 727–733, 1983

    Google Scholar 

  • Wigler, M., Sweet, R., Sim, G. K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R.: Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell 16: 777–785, 1979

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamamoto, K., Floyd-Smith, G., Francke, U. et al. The gene encoding the Ia-Associated invariant chain is located on chromosome 18 in the mouse. Immunogenetics 21, 83–90 (1985). https://doi.org/10.1007/BF00372244

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00372244

Keywords

Navigation