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Genetic studies on natural resistance to Moloney lymphoma (YAC) isografts. I. Introduction of a non-H-2-linked resistance gene on strain A/Sn background

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Abstract

YAC is a Moloney-virus-induced lymphoma of strain A/Sn origin that is highly sensitive to natural killing (NK) in vitro and NK-mediated hybrid resistance in vivo. Previous studies have shown that hybrid resistance is under polygenic control that includes bothH-2-linked and non-H-2-linked factors. For further analysis on the genetics and immunology of hybrid resistance, we are at present developing congenic resistant lines on an A/Sn strain background. Following an outcross to a strain that conveys strong hybrid resistance on the F1 offspring, the mice are challenged with small viable inocula of YAC. Survivors are backcrossed to A/Sn. This is followed by repeated YAC challenge and backcrossing. We now report the successful establishment of a first resistant strain, designated A.LRA. It is relatively resistant to small inocula of YAC cells due to a single, non-H-2-linked dominant gene introduced from the C57L strain.

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Authors and Affiliations

  1. Department of Tumor Biology, Karolinska Institutet, S 104 01, Stockholm, Sweden

    Lars Ährlund-Richter, George Klein & Eva Klein

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  1. Lars Ährlund-Richter
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  2. George Klein
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  3. Eva Klein
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Ährlund-Richter, L., Klein, G. & Klein, E. Genetic studies on natural resistance to Moloney lymphoma (YAC) isografts. I. Introduction of a non-H-2-linked resistance gene on strain A/Sn background. Immunogenetics 18, 221–227 (1983). https://doi.org/10.1007/BF00952961

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  • DOI: https://doi.org/10.1007/BF00952961

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