Abstract
Two new recombinant haplotypes of the rat major histocompatibility system,RT1, have been detected in [LEW.1A (RT1 a) ×LEW.1W (RT1 u)] × LEW 1N(RT1 n) segregating hybrids. Recombinantr3 carries theRTL1. A region (determining classical transplantation antigens) and theRT1.B region (determining strong mixed lymphocyte reactivity and genetic control of antipolypeptide immune responsiveness) of the RT1a parent, bur rejects RT1a skin grafts. Recombinantr4 carries theA andB regions of the RT1u parent, but rejects RT1u skin grafts. The two histocompatibility genes detected are allelic to each other. The relevant locus, designated asH-C, maps to theB-region side of theRT1 system and appears to mark a thirdRT1 gene region,RT1.C. Availability of haplotypes r3 andr4 allowed the definition of a histocompatibility locus in theB region,H-B. The products ofH-C, H-B and of the previously describedH-A gene vary in antigenic strength.
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Kohoutavá, M., Günther, E. & Štark, O. Genetic definition of a further gene region and identification of at least three different histocompatibility genes in the rat major histocompatibility system. Immunogenetics 11, 483–490 (1980). https://doi.org/10.1007/BF01567816
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DOI: https://doi.org/10.1007/BF01567816