Summary
The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects.
There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the pharmacokinetics of propranolol, a flow limited drug, is marked but variable.
This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.
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Frank, S., Somani, S.M. & Kohnle, M. Effect of exercise on propranolol pharmacokinetics. Eur J Clin Pharmacol 39, 391–394 (1990). https://doi.org/10.1007/BF00315416
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DOI: https://doi.org/10.1007/BF00315416