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Effect of terfenadine and ranitidine on histamine and suxamethonium wheals

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Summary

The effects of the H-1 receptor blocker terfenadine and the H-2 receptor blocker ranitidine have been experimentally tested in wheals induced with histamine and suxamethonium chloride.

Ranitidine alone in the standard and a four-fold higher dose did not notably reduce the size of the wheal and flare as compared to placebo. As expected, both parameters were markedly reduced by the H-1 antihistamine terfenadine in full and half-dosage. A combination of the two drugs both in “standard” and modified dosage resulted in the greatest reduction in the wheal and flare.

Histamine and suxamethonium-induced wheals reacted in a similar manner to the antihistamines.

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Authors and Affiliations

  1. Zentrum für Dermatologie und Andrologie, Hautklinik, Klinikum der Justus-Liebig-Universität, Gießen, FRG

    E. Paul & M. Pfeffer

  2. Institut für Medizinische Informatik, Gießen, FRG

    R. -H. Bödeker

Authors
  1. E. Paul
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  2. M. Pfeffer
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  3. R. -H. Bödeker
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Paul, E., Pfeffer, M. & Bödeker, R.H. Effect of terfenadine and ranitidine on histamine and suxamethonium wheals. Eur J Clin Pharmacol 34, 591–594 (1988). https://doi.org/10.1007/BF00615222

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  • DOI: https://doi.org/10.1007/BF00615222

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