Skip to main content
Log in

Flecainide – an intravenous infusion regimen

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

An intravenous infusion regimen for flecainide was studied in 12 patients. Therapeutic drug levels were rapidly established and maintained throughout the 48-h infusion period. Two patients were withdrawn because of possible drug related problems, but in general the regimen seemed both effective and well tolerated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Cowan JC, Vaughan Williams EM (1981) Characterisation of a new oral antiarrhythmic drug, flecainide (R818). Eur J Pharmacol 73: 333–342

    Google Scholar 

  2. Editorial (1984) Flecainide acetate. Lancet 1: 85–86

    Google Scholar 

  3. Legrand V, Vandormel M, Collognon P, Kulbertus HE (1983) Haemodynamic effects of a new antiarrhythmic agent, flecainide (R818), in coronary heart disease. Am J Cardiol 51: 422–426

    Google Scholar 

  4. Serruys PW, Vanhaleweyk G, Van den Brand M, Verdouw P, Lubsen J, Hugenholtz PG (1983) The haemodynamic effects of intravenous flecainide acetate in patients with coronary artery disease. Br J Clin Pharmacol 16: 51–59

    Google Scholar 

  5. Morganroth J, Horowitz LN (1984) Flecainide: Its proarrhythmic effect and expected changes on the surface electrocardiogram. Am J Cardiol 53: 89B-94B

    Google Scholar 

  6. Nathan AW, Hellestrand KJ, Bexton RS, Banim SO, Spurrell RAJ, Camm AJ (1984) Proarrhythmic effects of the new antiarrhythmic agent flecainide acetate. Am Heart J 107: 222–228

    Google Scholar 

  7. Holmes B, Heel RC (1985) Flecainide, A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs 29: 1–33

    Google Scholar 

  8. Bhamra RK, Flanagan RJ, Holt DW (1984) High-performance liquid chromatographic method for the measurement of mexiletine and flecainide in blood plasma or serum. J Chromatogr 307: 439–444

    Google Scholar 

  9. Conard GJ, Ober RE (1984) Metabolism of flecainide. Am J Cardiol 53: 41B-51B

    Google Scholar 

  10. Johnston A, Warrington S, Turner P (1985) Flecainide pharmacokinetics in healthy volunteers: the influence of urinary pH. Br J Clin Pharmacol 20: 333–338

    Google Scholar 

  11. Kertes P, Hunt D (1984) Prophylaxis of primary ventricular fibrillation in acute myocardial infarction. The case against lignocaine. Br Heart J 52: 241–247

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cowan, J.C., Holt, D.W., Bexton, R.S. et al. Flecainide – an intravenous infusion regimen. Eur J Clin Pharmacol 32, 195–198 (1987). https://doi.org/10.1007/BF00542195

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00542195

Key words

Navigation