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The evaluation of histamine antagonists in man

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Summary

A new method for evaluating histamine antagonists in man is described based on diminution of the effects of intradermal histamine. The inter and intra subject variability of such effects is examined experimentally and previous descriptions reviewed. Measures are adopted to minimise the effects and so achieve maximum economy of drug administrations and subjects. The method is exemplified by comparisons of activity of different preparations of triprolidine and of cyclizine and chlorcycline.

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Authors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, Great Britain

    A. S. E. Fowle, D. T. D. Hughes & G. J. Knight

Authors
  1. A. S. E. Fowle
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  2. D. T. D. Hughes
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  3. G. J. Knight
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Fowle, A.S.E., Hughes, D.T.D. & Knight, G.J. The evaluation of histamine antagonists in man. Eur J Clin Pharmacol 3, 215–220 (1971). https://doi.org/10.1007/BF00565009

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  • DOI: https://doi.org/10.1007/BF00565009

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