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Influence of prenylamine on the cardiovascular effects of tyramine, noradrenaline and adrenaline in man

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Summary

The effect of prenylamine on the cardiovascular effects of intravenously infused directly and indirectly acting sympathomimetic amines was investigated in 5 healthy volunteers. — 1. After oral administration of 180 mg/day prenylamine for 9 days, the pressor effect of the indirect sympathomimetic tyramine (3 mg/min over 6 min) was markedly diminished. — 2. Under the same experimental conditions the rise in blood pressure after i.v. infusion of 15 µg/min noradrenaline and 30 µg/min adrenaline, resp., for 6 min, was significantly increased. — 3. Treatment for 9 days with prenylamine produced a relative prolongation of the pressor effects of noradrenaline and adrenaline. Prolongation of the pressor action of the indirectly acting sympathomimetic tyramine was also observed despite a diminution in its maximum pressor effect. — 4. The urinary excretion of catecholamines (noradrenaline plus adrenaline) and their 0-methylated derivatives was significantly enhanced during the administration of prenylamine. Excretion of 3-methoxy-4-hydroxyphenylglycol decreased, whereas vanilmandelic acid and 5-hydroxyindole acetic acid excretion were not significantly affected. — 5. These results are compatible with the assumption that prenylamine in therapeutic doses interferes mainly with the sympathomimetic amine transport mechanisms located in the cytoplasmic membranes of sympathetic nerves and other cells. Our results do not support the assumption of a reserpine-like action of this drug in man.

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Author notes

  1. B. May

    Present address: Abteilung für Gastroenterologie und Hepatologie, Medizinische Klinik, Medizinische Hochschule, Hannover, Germany

Authors and Affiliations

  1. Pharmakologisches Institut der Universität, Frankfurt am Main, Germany

    H. Grobecker, B. Schmid, H. -J. Fengler, D. Palm & K. Quiring

  2. Gastroenterologische Abteilung des Zentrums der Inneren Medizin, J.W. Goethe-Universität, Frankfurt am Main, Germany

    B. May, D. Helmstaedt & H. K. Moon

Authors
  1. H. Grobecker
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  2. B. Schmid
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  3. H. -J. Fengler
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  4. D. Palm
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  5. K. Quiring
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  6. B. May
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  7. D. Helmstaedt
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  8. H. K. Moon
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Additional information

A preliminary report of this work was given to the 75. Tagung der Deutschen Gesellschaft für innere Medizin, Wiesbaden 1969 (Schmidet al., 1969).

This work was supported by a grant from the Deutsche Forschungsgemeinschaft.

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Grobecker, H., Schmid, B., Fengler, H.J. et al. Influence of prenylamine on the cardiovascular effects of tyramine, noradrenaline and adrenaline in man. Eur J Clin Pharmacol 3, 137–143 (1971). https://doi.org/10.1007/BF00572453

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