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The effect of orally administered triprolidine and pseudoephedrine singly and combined on histamine-induced skin reactions

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Summary

The effect of a single oral dose of triprolidine and pseudoephedrine, singly and combined, on histamine-induced wheal and flare reactions, was assessed in a fully randomised, placebo-controlled, double-blind crossover study. Triprolidine alone and the combination had a significantly greater effect (p<0.05) in reducing skin reactions than pseudoephedrine alone or placebo, but there was no significant difference between triprolidine and the combination (p<0.05).

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Authors and Affiliations

  1. Department of Clinical Investigation, Wellcome Research Laboratories, Beckenham, England

    J. R. Gibson, K. T. Medder, K. A. McDonnell, C. E. Bye & D. T. D. Hughes

Authors
  1. J. R. Gibson
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  2. K. T. Medder
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  3. K. A. McDonnell
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  4. C. E. Bye
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  5. D. T. D. Hughes
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Work carried out at the Wellcome Research Laboratories, Beckenham, England

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Gibson, J.R., Medder, K.T., McDonnell, K.A. et al. The effect of orally administered triprolidine and pseudoephedrine singly and combined on histamine-induced skin reactions. Eur J Clin Pharmacol 22, 411–412 (1982). https://doi.org/10.1007/BF00542544

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  • DOI: https://doi.org/10.1007/BF00542544

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