Summary
The effect of a single oral dose of triprolidine and pseudoephedrine, singly and combined, on histamine-induced wheal and flare reactions, was assessed in a fully randomised, placebo-controlled, double-blind crossover study. Triprolidine alone and the combination had a significantly greater effect (p<0.05) in reducing skin reactions than pseudoephedrine alone or placebo, but there was no significant difference between triprolidine and the combination (p<0.05).
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Britton MG, Empey DW, John GC, Hodder M, Hughes DTD (1979) Two doses of triprolidine for treatment of allergic rhinitis. Ann Allergy 42/5: 330–332
Drew CDM, Knight GT, Hughes DTD, Bush M (1978) Comparison of the effects of D-(-)-ephedrine and L-(+)-pseudoephedrine on the cardiovascular and respiratory system in man. Br J Clin Pharmacol 6: 221–225
Empey DW, Bye C, Hodder M, Hughes DTD (1975) A doubleblind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergenic rhinitis. Ann Allergy 34/1: 41–46
Empey DW, Young GA, Letley E, John GC, Smith P, McDonnell KA, Bagg LR, Hughes DTD (1980) Dose-response study of the nasal decongestant and cardiovascular effects of pseudoephedrine. Br J Clin Pharmacol 9: 351–358
Fowle ASE, Hughes DTD, Knight GJ (1971) The evaluation of histamine antagonists in man. Eur J Clin Pharmacol 3: 215–220
Greaves MW (1979) Agents which inhibit histamine-mediated reactions. Clin Exp Dermatol 4: 147–149
Kennes B, De Maubeuge J, Delespesse G (1977) Treatment of chronic urticaria with a beta2-adrenergic stimulant. Clin Allergy 7: 35–39
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Work carried out at the Wellcome Research Laboratories, Beckenham, England
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Gibson, J.R., Medder, K.T., McDonnell, K.A. et al. The effect of orally administered triprolidine and pseudoephedrine singly and combined on histamine-induced skin reactions. Eur J Clin Pharmacol 22, 411–412 (1982). https://doi.org/10.1007/BF00542544
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DOI: https://doi.org/10.1007/BF00542544