Conclusions
Formation of the uroporphyrin isomers II and IV in urines of patients with AIP can be explained by non-enzymatic self-condensation of PBG. Presence of the coproporphyrin isomers II and IV, however, must be due to enzymatic processes, the nature of which have to be clarified.
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Jacob, K., Egeler, E., Hennel, B. et al. Improved separation of porphyrin isomers from human urines by isocratic ion-pair HPLC. Z. Anal. Chem. 330, 386–387 (1988). https://doi.org/10.1007/BF00469306
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DOI: https://doi.org/10.1007/BF00469306