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Dünnschicht-chromatographische und fluorimetrische Charakteristica einiger Psychopharmaka der Thioxanthen- und Dibenz[a,d]-1,4-cycloheptadien-Reihe

Thin-layer chromatography and fluorimetric characteristics of some psychotherapeutics of the thioxanthene and dibenzo(a,d)-1,4-cycloheptadiene series

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Abstract

TLC characteristics are described of some psychopharmacological agents (Chlorprothixen, Prothixen, Clopenthixol, Flupentixol, Meprotixol, Amitriptylin und Nortriptylin) and of their metabolites and derivatives in six different developing solvent systems as well as the fluorescence maxima of these compounds in 60% sulphuric acid.

By way of the examples of Chlorprothixen and Chlorprothixen sulphoxide the isolation of reactive agents from biological material and their determination are shown.

The determination of Clopenthixol and Flupentixol in mixtures with their corresponding metabolites is possible due to differences in their fluometric spectra.

Zusammenfassung

DC-Charakteristica einiger Psychopharmaka (Chlorprothixen, Prothixen, Clopenthixol, Meprotixol, Amitriptylin und Nortriptylin), deren Metaboliten und Derivate in 6 verschiedenen azeotropen Laufmittelsystemen werden beschrieben und die Fluorescenzmaxima dieser Verbindungen in 60%iger Schwefelsäure angegeben. Am Beispiel des Chlorprothixens und Chlorprothixensulfoxids wird die gemeinsame sowie separate Isolierung und quantitative Bestimmung von Wirkstoffen aus biologischem Material gezeigt. Fluorimetrische Unterschiede bei Clopenthixol und Flupentixol gegenüber deren Metaboliten ermöglichen die Bestimmung der Wirksubstanzen im Gemisch.

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Authors and Affiliations

  1. Biochemische Abteilung der Troponwerke, Köln-Mülheim

    H. -D. Dell, J. Fiedler & R. Teichgräber

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  1. H. -D. Dell
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  2. J. Fiedler
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  3. R. Teichgräber
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Dell, H.D., Fiedler, J. & Teichgräber, R. Dünnschicht-chromatographische und fluorimetrische Charakteristica einiger Psychopharmaka der Thioxanthen- und Dibenz[a,d]-1,4-cycloheptadien-Reihe. Z. Anal. Chem. 249, 41–44 (1970). https://doi.org/10.1007/BF00427245

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  • DOI: https://doi.org/10.1007/BF00427245

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