Skip to main content
SpringerLink
Log in

Routes to F3-etidronic acid (1-hydroxy-2,2,2 trifluoroethylidene-bisphosphonic acid), molecular structure of the tris(trimethylsilyl)ester, antimineralization, and antiresorption effects of the disodium salt

  • Short Communications
  • Published:
Naturwissenschaften Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Fleisch, H.: Chemistry and Mechanism of Action of Bisphosphonates, in:Bone Resorption Metathesis, and Diphosphonates, p. 33 (S. Garattini, ed.). New York; Raven 1985; (b) Zolotukhina, M. M., Krutikov, V. I., Lavrentiev,A. N.: Usp. Khim.62, 691 (1993)

    Google Scholar 

  2. Fleisch, H. A., Russell, R. G. G., Bisaz, S., Muhlbauer, R. C., Williams, D. A.: Europ. J. Clin. Invest.1, 12 (1970); Levy, R. J., Wolfrum, J., Schoen, F. J., Hawley, M. A., Lund, S. A., Langer, R.: Science228, 190 (1985)

    Google Scholar 

  3. Filler, R., Kobayashi, Y., Yagupolskij, L. M.:Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications. Amsterdam: Elsevier 1993

    Google Scholar 

  4. Resnati, G.: Tetrahedron49, 9385 (1993)

    Google Scholar 

  5. Welch, J. T., Eswarakrishnan, S.: Fluorine in Biorganic Chemistry, p. 113. New York: Wiley 1991

    Google Scholar 

  6. Nair, H. K., Guneratne, R. D., Modak, A. S., Burton, D. J.: J. Org. Chem.59, 2393 (1994)

    Google Scholar 

  7. Dietsch, P., Gunther, T., Rohnelt, M.: Z. Naturforsch.31C, 661–663 (1976)

    Google Scholar 

  8. Woznbiak, L., Chojnowski, J.: Tetrahedron45, 2465 (1989)

    Google Scholar 

  9. Sekine, M., Okimoto, K., Yamada, K., Hata, T.: J. Org. Chem.46, 2097 (1981)

    Google Scholar 

  10. Kutyrev,G. A., Cherkasov, R. A.: Usp. Khim.53, 1675 (1984)

    Google Scholar 

  11. Heine, J., Röschenthaler, G.-V.: Z. Naturforsch.43b, 196 (1988)

    Google Scholar 

  12. Wessolowski, H., Röschenthaler, G.-V., Winter, R., Gard, G. L.: Phosphorus, Sulfur & Silicon60, 201 (1991)

    Google Scholar 

  13. Seifert,F. U., Roschenthaler, G.-V.:J. Fluorine Chem.68, 169 (1994)

    Google Scholar 

  14. Dyakov, V. M., Voronkov, M. G.: Izv. Akad. Nauk SSSR, Set. Khim. 399 (1973)

  15. Sekine, M., Hata, T.: J. Chem. Soc. Chem. Commun. 285 (1978)

  16. Breuer, E., in:The chemistry of organophosphorus compounds, Vol 4, p.653 (F. R. Hartley, ed.). New York: Wiley 1996

    Google Scholar 

  17. Ruel, R., Bouvier, J. P., Young, R. N.: J. Org. Chem.60, 5209 (1995)

    Google Scholar 

  18. Keumi, T., Shimada, M., Morita, T., Kitajima, H.: Bull. Chem. Soc. Jpn.63, 2252 (1990)

    Google Scholar 

  19. Uchtman,V. A., Gloss, R. A.: J. Phys. Chem.76, 1298 (1972)

    Google Scholar 

  20. Sheldrick, W. S.: J. Chem.Soc. Dalton Trans. 943 (1975)

  21. Schoen, F. J., Levy,R. J., Nelson, A. C., Bernhard, W.F., Nashef, A., Hawley, M.: Lab. Invest.52, 523 (1985)

    Google Scholar 

  22. Golomb, G.: J. Biomat. Appl.2, 266 (1987)

    Google Scholar 

  23. Van Gelder, J. M., Golomb, G., in:Animal models of human related calcium metabolic disorders, p.181 (A. Ornoy, ed.). Boca Raton, CRC 1995

    Google Scholar 

  24. Golomb, G., Schlossman, A., Saadeh, H., Levi, M., Van Gelder, J. M., Breuer, E.: Pharm. Res.9, 143 (1992); Golomb, G., Schlossman, A., Eitan, Y., Saadeh, H., Van Gelder, J. M., Breuer, E.: J. Pharm. Sci.81, 1004 (1992)

    Google Scholar 

  25. Van Gelder, J. M., Breuer, E., Ornoy, A., Schlossman, A., Patlas, N., Golomb, G.: Bone16, 511 (1995)

    Google Scholar 

  26. Levy, R. J., Schoen,F. J., Levy, J. T., Nelson, A. C., Howard, S. L., Oshry, L.: J. Am. J. Pathol.113, 142 (1983)

    Google Scholar 

  27. Hirsch, D., Schoen, E. J., Levy, R. J.: Biomaterials14, 371 (1993)

    Google Scholar 

  28. Francis,M. D.: Calc. Tiss. Res.3, 151 (1969)

    Google Scholar 

  29. Golomb, G., Wagner, D.: Trans. Soc. Biomat.13, 129 (1990)

    Google Scholar 

  30. Golomb, G., Wagner, D.: Biomaterials12, 397 (1991)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Anorganische und Physikalische Chemie, Universität Bremen, Leobener Strasse, D-28334, Bremen, Germany

    R. -M. Schoth, E. Lork, F. U. Seifert & G. -V. Röschenthaler

  2. Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, 91120, Jerusalem, Israel

    H. Cohen & G. Golomb

  3. Department of Pharmaceutical Chemistry, School of Pharmacy, Hebrew University of Jerusalem, 91120, Jerusalem, Israel

    E. Breuer

Authors
  1. R. -M. Schoth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Lork
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. U. Seifert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. -V. Röschenthaler
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Golomb
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. Breuer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schoth, R.M., Lork, E., Seifert, F.U. et al. Routes to F3-etidronic acid (1-hydroxy-2,2,2 trifluoroethylidene-bisphosphonic acid), molecular structure of the tris(trimethylsilyl)ester, antimineralization, and antiresorption effects of the disodium salt. Naturwissenschaften 83, 571–574 (1996). https://doi.org/10.1007/BF01141983

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01141983

Keywords

Search

Navigation