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A New Method for the Determination of Partition Coefficients of Air Sensitive Copper(I) Complexes

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Abstract

Determinations of log P values of copper complexes in oil/water were performed in a new, totally closed apparatus connected with a filter-probe extractor. The results indicate that the system may be generally suitable for the determination of log P values of oxidizable and nonoxidizable metal complexes. In the case of the copper (I) complexes spectrophotometric analysis was not feasible, since 1-octanol was extracted by these complexes into the aqueous phase, resulting in a change in the extinction coefficient. To establish accurately the concentration in each phase, copper was determined by atomic absorption spectrometry.

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Authors and Affiliations

  1. Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands

    Hans-Dieter Gaisser, Henk van der Goot & Henk Timmerman

Authors
  1. Hans-Dieter Gaisser
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  2. Henk van der Goot
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  3. Henk Timmerman
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Gaisser, HD., van der Goot, H. & Timmerman, H. A New Method for the Determination of Partition Coefficients of Air Sensitive Copper(I) Complexes. Pharm Res 2, 181–184 (1985). https://doi.org/10.1023/A:1016392123137

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  • DOI: https://doi.org/10.1023/A:1016392123137

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