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In Vivo Absorption Properties of Orally Administered Recombinant Human Interleukin-11

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REFERENCES

  1. M. Czupryn, F. Bennett, J. Dube, K. Grant, H. Scoble, H. Sookdeo, and J. M. McCoy. Alanine-scanning mutagenesis of human interleuken 11: identification of regions important for biological activity. Ann. N. Y. Acad. Sci. 762:152–164 (1995).

    Google Scholar 

  2. S. J. Goldman. Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity. Stem Cells (Dayt) 13:462–471 (1995).

    Google Scholar 

  3. R. L. Peterson, L. Wang, L. Albert, J. C. Keith, Jr., and A. J. Dorner. Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. Lab. Invest. 78:1503–1512 (1998).

    Google Scholar 

  4. W. L. Trepicchio, M. Bozza, G. Pedneault and A. J. Dorner. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J. Immunol. 157:3627–3634 (1996).

    Google Scholar 

  5. A. Takagi, H. Masuda, Y. Takakura, and M. Hashida. Disposition characteristics of recombinant human interleukin-11 after a bolus intravenous administration in mice. J. Pharmacol. Exp. Ther. 275:537–543 (1995).

    Google Scholar 

  6. T. Uchida, K. Aoyama, K. Mori, T. Usui, T. Watanabe, Y. Takariki, N. Asahara, M. Hirose, T. Kimura, M. Tateishi, and S. Higuchi. Pharmacokinetics of [125I]-recombinant human interleukin-11:1 Absorption, distribution and excretion after subcutaneous administration to male rats. Eur. J. Drug Metab. Pharmacokinet. 23: 403–410 (1998).

    Google Scholar 

  7. K. Aoyama, T. Uchida, F. Takanuki, T. Usui, T. Watanabe, S. Higuchi, T. Toyoki, and H. Mizoguchi. Pharmacokinetics of recombinant human inteleukin-11 (rhIL-11) in healthy male subjects. Br. J. Clin. Pharmacol. 43:571–578 (1997).

    Google Scholar 

  8. D. J. Hnatowich, W. W. Layne, and R. L. Childs. The preparation and labeling of DTPA-coupled albumin. Int. J. Appl. Radiat. Isot. 33:327–332 (1982).

    Google Scholar 

  9. H. Baumann, and J. Gauldie. The acute phase response [see comments]. Immunol. Today 15:74–80 (1994).

    Google Scholar 

  10. S. Neben, and K. Turner. The biology of interleukin 11. Stem Cells (Dayt) 11 Suppl 2: 156–162 (1993).

    Google Scholar 

  11. M. S. Gordon, W. J. McCaskill-Stevens, L. A. Battiato, J. Loewy, D. Loesch, E. Breeden, R. Hoffman, K. J. Beach, B. Kuca, J. Kaye, and G. W. Sledge, Jr. A phase I trial of recombinant human inteleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. Blood 87:3615–3624 (1996).

    Google Scholar 

  12. C. Gabay, and I. Kushner. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340:448–454 (1999).

    Google Scholar 

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Authors and Affiliations

  1. Department of Preclinical Research and Development, Genetics Institute of Wyeth-Ayest Research, Andover, Massachusettes, 01810

    Chih-Ming Leo Tseng, Leo Albert, Ron L. Peterson, Page Bouchard, Andrew J. Dorner, James Keith Jr. & Soo-Peang Khor

  2. Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., Thousand Oaks, California, 91320

    Chih-Ming Leo Tseng

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  1. Chih-Ming Leo Tseng
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  2. Leo Albert
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  3. Ron L. Peterson
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  4. Page Bouchard
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  5. Andrew J. Dorner
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  6. James Keith Jr.
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  7. Soo-Peang Khor
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Tseng, CM.L., Albert, L., Peterson, R.L. et al. In Vivo Absorption Properties of Orally Administered Recombinant Human Interleukin-11. Pharm Res 17, 482–485 (2000). https://doi.org/10.1023/A:1007545524408

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