REFERENCES
K. T. Heruth. Medtronic synchromed drug administration system. Ann. N. Y. Acad. Sci. 531:72–75 (1988).
J. Kost, K. Leong, and R. Langer. Ultrasound-enhanced polymer degradation and release of incorporated substances. Proc. Natl. Acad. Sci. U.S.A. 86:7663–7666 (1989).
E. R. Edelman, L. Brown, J. Taylor, and R. Langer. In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields. J. Biomed. Mater Res. 21:339–353 (1987).
J. Kost and R. Langer. Responsive polymeric delivery systems. Adv. Drug. Del. Rev. 6:19–50 (1991).
J. B. Phipps and J. A. Gyory. Transdermal ion migration. Adv. Drug Del. Rev. 9:137–176 (1992).
G. B. Kasting. Theoretical models for iontophoretic delivery. Adv. Drug Del. Rev. 9:177–199 (1992).
S. P. Schwendeman, G. L. Amidon, M. E. Meyerhoff, and R. J. Levy, Modulated drug release using iontophoresis through heterogeneous cation-exchange membranes: membrane preparation and influence of resin cross-linkage. Macromolecules 25:2531–2540 (1992).
S.P. Schwendeman, G. L. Amidon, V. Labhasetwar, and R. J. Levy, Modulated drug release using iontophoresis through heterogeneous cation-exchange membranes II: influence of cation-exchanger content on membrane resistance and characteristic times. J. Pharm Sci., 83:1482–1494 (1994).
S. P. Schwendeman, G. L. Amidon, and R. J. Levy, Determinants of the modulated release of antiarrhythmic drugs by iontophoresis through polymer membranes. Macromolecules 26:2264–2272 (1993).
J. W. Boretos. Silicones. Polym. Sci. Technol. 8:87–98 (1975).
A. Waldo and A Wit. Mechanisms of cardiac arrhythmias. The Lancet 341:1189–1193 (1993).
A. Sintov, W. A. Scott, R. Siden, and R. J. Levy. Efficacy of epicardial controlled-release lidocaine for ventricular tachycardia induced by rapid ventricular pacing in dogs. J. Cardiovasc. Pharmacol. 16:812–817 (1990).
V. Labhasetwar, A. Kadish, T. Underwood, M. Sirinek, and R. J. Levy. The efficacy of controlled release d-sotalol-polyurethane epicardial implants for ventricular arrhythmias due to acute ischemia in dogs. J. Controlled Release 23:75–86 (1993).
A. Sintov, W. A. Scott, K. P. Gallagher, and R. J. Levy. Conversion of ouabain-induced ventricular tachycardia in dogs with epicardial lidocaine: pharmacodynamics and functional effects. Pharm. Res. 7:28–33 (1990).
A. Sintov., W. Scott, M. Dick, and R. J. Levy. Cardiac controlled release for arrhythmia therapy: lidocaine-polyurethane matrix studies. J. Controlled Release 8:157–168 (1988).
R. Siden, A. Kadish, W. Flowers, L. Kutas, B. K. Bieneman, J. DePietro, J. P. Jenkins, K. P. Gallagher, and R. J. Levy. Epicardial controlled-release verapamil prevents ventricular tachycardia episodes induced by acute ischemia in a canine model. J. Cardiocasc. Pharmacol. 19:798–809 (1992).
V. Labhasetwar, T. Underwood, M. Gallagher, G., Murphy, J. Langberg, and R. J. Levy, Sotalol controlled-release systems for arrhythmias: in vitro characterization, in vivo drug disposition, and electrophysiologic effects. J. Pharm. Sci., 83:157–169 (1994).
V. Labhasetwar, T. Underwood, M. Gallagher, J. Langberg, and R. J. Levy. Epicardial controlled-release ibutilide: effects on defibrillation threshold and electrophyiologic parameters. J. Cardiovasc. Pharmacol. 24:826–840 (1994).
W. Chen, S. P. Schwendeman, V. Labhasetwar, and R. J. Levy. Techniques in cardiovascular drug delivery-surfactant derivatization, polymer implants, and iontophoresis, in Polymeric Site-specific Pharmacotherapy, A. J. Domb (ed.), John Wiley & Sons, N.Y., 1994, pp. 221–242.
V. Labhasetwar, T. Underwood, S. P. Schwendeman, and R. J. Levy. Iontophoresis for modulation of cardiac drug delivery. Proc. Natl. Acad. Sci USA, in press.
S. P. Schwendeman, R. J. Levy, H. A. Murphy, and G. L. Amidon. Influence of the silicone rubber matrix on the iontophoretc transport through heterogeneous cation-exchange membranes. Pharm. Res. 8:S-141 (1991).
J. O'M. Bockris and A. K. N. Reddy. Modern Electrochemistry Vol I., Plenum Press, N.Y., 1970.
W. E. Morf. The Principles of Ion-selective Electrodes and of Membrane Transport, Elsevier Scientific Publishing Company, N.Y., 1981.
K. J. Vetter. Electrochemical Kinetics, Academic Press, N.Y., 1967.
H. G. Mond. Permanent cardiac pacemakers: techniques of implantation, testing and surveillance, in Hurst's The Heart, R. C. Schlant, R. W. Alexander, W. O'Rourke, R. Roberts, and E. H. Sonnenblick (eds.), McGraw Hill, Inc., N. Y., 1994, p. 823.
The Merck Index, 11th ed., Merck&Co., Inc., Rahway, NJ, 1982.
R. C. Reid, J. M. Prausnitz, and T. K. Sherwood. The Properties of Gases and Liquids, 3rd ed., McGraw Hill Book Company, N. Y., 1977.
Perry's Chemical Engineers' Handbook, 6th ed., R. H. Perry and D. Green (eds.), McGraw-Hill Book Company, N. Y., 1984, pp. 3–76, 3–83.
J. N. Agar. Diffusion and convection at electrodes. Disc Faraday. Soc., 1:26–37 (1947).
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Schwendeman, S.P., Labhasetwar, V. & Levy, R.J. Model Features of a Cardiac lontophoretic Drug Delivery Implant. Pharm Res 12, 790–795 (1995). https://doi.org/10.1023/A:1016288315617
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DOI: https://doi.org/10.1023/A:1016288315617