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Importance of Structural Free Space to the Solvent Power of Water

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Abstract

The contribution of structural free space to the solvent power of water was examined by a systematic modification of the geometric factor. Gaps and holes, available to foreign molecule occupation, are thought to be filled at low concentrations (max. 1 %) of aliphatic alcohols. The effect upon solvency reached approximately 10%, which suggests that spatial parameters affect solvent power. The results demonstrate the importance of solvent purity in the dissolution process.

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Authors and Affiliations

  1. Department of Research and Development, VEB Jenapharm, Otto-Schott-Straβe 13, DDR-6900, Jena

    Reinhard Hüttenrauch, Petra Zielke & Sabine Fricke

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  1. Reinhard Hüttenrauch
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  2. Petra Zielke
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  3. Sabine Fricke
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Hüttenrauch, R., Zielke, P. & Fricke, S. Importance of Structural Free Space to the Solvent Power of Water. Pharm Res 1, 137–139 (1984). https://doi.org/10.1023/A:1016384205333

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