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Dynamic response of the intact canine adrenal to infused ACTH

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Abstract

The dynamic response of adrenocortical secretion of cortisol to intravenous infusion of ACTH was studied in 11 dogs 2 hr after hypophysectomy. This response was then compared to the response of the isolated adrenal perfusedin situ with ACTH, studied by Urquhartet al. (1968a,b). The comparison was facilitated by analysis in the frequency domain, effected by Fast Fourier Transform. The mode time for rise to 80% of steady-state secretion rate was 3 min faster for the infused preparation, despite the fact that in this preparation ACTH was distributed in blood and metabolized in part prior to presentation to the adrenal. Power spectral analysis revealed 1.6 times as high frequency power in the response of the infused preparation as in that of the perfused preparation. Complex division of the frequency-domain representations of the two responses led to identification of a transfer function to preface a previously reported model of adrenal response. This transfer function was a negative time delay of 2.6 min. The results indicate that the intact adrenal is dynamically more responsive than is thein situ perfused adrenal. The dynamic description obtained herein can be used for inference of proximal dynamic elements of the adrenocortical control system by a procedure of deconvolution similar to that defined in this paper.

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Author notes

  1. Donald S. Gann

    Present address: Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland

Authors and Affiliations

  1. Case Western Reserve University, 21205, Baltimore, Maryland

    Robin B. Lake &  Donald S. Gann

  2. Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland

    Robin B. Lake

Authors
  1. Robin B. Lake
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  2. Donald S. Gann
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Additional information

Supported in part by grants AM 14952, AM 14965 and GM 12302 of the NIH.

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Lake, R.B., Gann, D.S. Dynamic response of the intact canine adrenal to infused ACTH. Ann Biomed Eng 1, 56–68 (1972). https://doi.org/10.1007/BF02363418

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  • DOI: https://doi.org/10.1007/BF02363418

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