Summary
In the slime mold Dictyostelium discoideum polyisoprenylphosphomannosides are substrates for membrane bound mannosyltransferases; the isolated and purified isoprenyl derivatives transfer mannose to protein in vitro in presence of membrane fractions. The biosynthesis of the mannolipids as well as the biosynthesis of a glucose containing cerebroside, which becomes synthesized in an early stage of the cell development proceeds under control of the cell differentiation. The isolation procedure and the properties of the glycolipids are described, and their functions for the cellular development are discussed.
Similar content being viewed by others
References
Cook G. M. W., Laico M. T. and Eylar E. H., 1965., Proc. Natl. Acad. Sci. U.S. 54, 247–52.
Shur B. D. and Roth S., 1975., Biochim. Biophys. Acta 415, 473–512.
Schachter H., Jabbai J., Hodgin R., Pinteric L., McGuire E., and Roseman S., 1970., J. Biol. Chem. 245, 1090–1100.
Rogge H. and Risse H. J., 1974., Hoppe Seylers Z. Phyiol. Chem. 355, 1244–45.
Richard M., Martin A. and Louisot P., 1975., Biochem. Biophys. Res. Commun. 64, 108–14.
Waechter C. J. and Lennarz W., 1976., Ann. Rev. Biochem. 45, 95–112.
Higashi Y., Strominger J. L. and Sweeley C. C., 1967. Proc. Natl. Acad. Sci. U.S. 57, 1878.
Tanner W., 1969., Biochem. Biophys. Res. Commun. 35, 144–50.
Barr R. M. and Hemming E. W., 1972. Biochem. J. 126, 1203–08.
Kauss H., 1969. FEBS-Letters 5, 81–84.
Villemez C. L., 1970. Biochem. Biophys. Res. Commun. 36, 57–63.
Risse H. J., Rogge H., Rath M., Rothe G. Platzek F., 1974. ‘Biomembranes, Architecture, Biogenesis, Bioenergetics and Differentiation’ (ed. L. Packer) 371–79, Academic Press, New York.
Rogge H., Neises M. and Risse H. J., 1977. Biochim. Biophys. Acta 499, 273–77.
Wilhelms O. H., Lüderitz O., Westphal O. and Gerisch G., 1974. Europ. J. Biochem. 48, 89–101.
Crean E. V. and Rossomando E. F., 1977. Biochim. Biophys. Acta 498, 439–41
Watts D. J. and Ashworth J. M., 1970. Biochem. J. 119, 171–74
Bauer R., Rath M. and Risse H. J., 1971 Europ. J. Biochem. 21, 179–90.
Kates M. 1972. ‘Techniques of Lipidology,’ North Holland Publishers.
Trevelyan W. E., Procter D. P. and Harrison J. S., 1950. Nature 166, 444.
Richards J. B. and Hemming F. W., 1972. Biochem J. 130, 77–93.
Kerman R. W., Kruczek M. and Fusinato L., 1975. Arch. Biochem. Biophys. 167, 697–705.
Baynes J. W., Hsu A. F. Heath E. C., 1973. J. Biol. Chem. 248, 5693–704.
Kean E. L., 1977. J. Biol. Chem. 252, 5622–27.
Herscovics A., Golovtchenko A. M., Warren C. D., Bugge B. and Jeanloz R. W., 1977. J. Biol. Chem. 252, 224–34.
Arnold D., Hommel E. Risse H. J., 1973. Biochem. Biophys. Res. Commun. 54, 100–107.
Arnold D., Hommel E. Risse H. J., 1975, J. Mol. Cell. Biochem. 10, 81–95.
Arnold D., Hommel E. and Risse H. J., 1976, J. Mol. Cell. Biochem. 11, 137–47.
Behrens N. H. and Leloir L. F., 1970., Proc. Natl. Acad. Sci. U.S. 66, 153–59.
Anam S. S., Barr R. M., Richards J. B. and Hemming F. W., 1970. Biochem. J. 121, 19 P.
Rosso G. C., DeLuca L., Warren C.D. and Wolf G., 1975. J. Lipid Res. 16, 235–43.
Riedel V. and Gerisch G., 1969. Wilhelm Roux' Archiv 162, 268–85.
Loomis Jr. W. F., 1970. J. Bacteriol. 103, 375–81.
Chambers J. and Elbein A. D., 1975. J. Biol. Chem. 250, 6904–15.
Eibl H. J. and Lands W. E. M., 1970. Biochemistry 9, 423–28.
Sievers S., Risse H. J. and Sekeri-Pataryas K., 1978. Mol. and Cellular Biochem. 20, 103–110.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rössler, H., Peuckert, W., Risse, H.J. et al. The biosynthesis of glycolipids during the differentiation of the slime mold dictyostelium discoideum. Mol Cell Biochem 20, 3–15 (1978). https://doi.org/10.1007/BF00229450
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00229450