Abstract
We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.
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REFERENCES
B. Korman, L. S. Jennings, and J. R. A. Rigg. Rapid attainment of steady-state plasma drug concentrations within precise limits. J. Pharmacokin. Biopharm. 26:319-328 (1998).
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Korman, B., Jennings, L.S. Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems. J Pharmacokinet Pharmacodyn 27, 325–328 (1999). https://doi.org/10.1023/A:1020951230947
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DOI: https://doi.org/10.1023/A:1020951230947