Abstract
The abnormal wing discs gene of Drosophila encodes a soluble protein with nucleosidediphosphate kinase activity. This enzymic activity is necessary for the biological function ofthe abnormal wing discs gene product. Complete loss of function, i.e., null, mutations causelethality after the larval stage. Most larval organs in such null mutant larvae appear to benormal, but the imaginal discs are small and incapable of normal differentiation.Killer-of-prune is a neomorphic mutation in the abnormal wing discs gene. It causes dominant lethalityin larvae that lack prune gene activity. The Killer-of-prune mutant protein may have alteredsubstrate specificity. Null mutant larvae have a low level of nucleoside diphosphate kinaseactivity. This suggests that there may be additional Drosophila genes that encode proteinswith nucleoside dipthosphate kinase activity. Candidate genes have been found in theDrosophila genome.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Aravind L., and Koonin, E. V. (1998). Trends Biochem. Sci. 23, 17-19.
Biggs, J., Tripoulas, N., Hersperger, E., Dearolf, C., and Shearn, A. (1988). Genes Develop. 2, 1333-1343.
Biggs, J., Hersperger, E., Steeg, P. S., Liotta, L. A., and Shearn, A. (1990). Cell 63, 933-940.
Bominaar, A. A., Tepper, A. D., and Veron, M. (1994). FEBS Lett. 353, 5-8.
Chen, M. S., Burgess, C. C., Vallee, R. B., Wadsworth, S.C. (1992). J. Cell Sci. 103, 619-628.
Chiadmi, M., Morera, S., Lascu, I., Dumas, C., LeBras, G., and Janin, J. (1993). Structure 1, 283-293.
Dearolf, C. R. (1986) Ph.D. Dissertation, Johns Hopkins University, Baltimore, Maryland.
Dearolf, C., Hersperger, E., and Shearn, A.(1988a). Develop. Biol. 129, 159-168.
Dearolf, C., Tripoulas, N., Biggs, J., and Shearn A. (1988b). Develop. Biol. 129, 169-178.
Dumas, C., Lascu, I., Morera, S., Glaser, P., Fourme, R., Wallet, V., Lacombe, M. L., Veron, M., and Janin, J. (1992). EMBO J. 11, 3203-3208.
Frolov, M. V., Zverlov, V. V., and Alatortsev, V. E. (1994). Mol. Gen. Genet. 242, 478-483.
Gateff, E., and Mechler, B.M. (1989). CRC Critical Rev. Oncogenesis 1, 221-245.
Gaul, U., Mardon, G., and Rubin, G. M. (1992). Cell 68, 1007-1019.
Hackstein, J. H. P. (1992). Eur. J. Cell Biol. 58, 429-444.
Inoue, H., Takahashi, M., Oomori, A., Sekiguchi, M., and Yoshioka, T. (1996). Biochem. Biophys. Res. Commun. 218, 887-892.
Kimura, N., and Johnson, G. S. (1983). J. Biol. Chem. 258, 12609-12617.
Kiss, I., Bencze, G., Fekete, E., Fodor, A., Gausz, J., Maroy, P., Szabad, J., and Szidonya, J. (1976). Theoret. Appl. Genet. 48, 217-226.
Lacombe, M., Wallet, V., Troll, H., and Veron, M. (1990). J. Biol. Chem. 265, 10012-10018.
Lascu, I., Chaffotte, A., Limbourg-Bouchon, B., and M. Veron (1992). J. Biol. Chem. 267, 12775-12781.
Lifshytz, E., and Falk, R. (1969). Genetics 62, 353-358.
Luo, H., Rose, P., Barber, D., Hanratty, W. P., Lee, S., Roberts, T. M., D'Andrea, A. D., and Dearolf, C. R. (1997). Mol. Cell Biol. 17, 1562-1571.
MacDonald, N. J., De la Rosa, A., Benedict, M. A., Freije, J. M., Krutsch, H., and Steeg, P. S. (1993). J. Biol. Chem. 268, 25780-25789.
Morera, S., Lascu, I., Dumas, C., LeBras, G., Briozzo, P., Veron, M., and Janin, J. (1994). Biochemistry 33, 459-467.
Munoz-Dorado, J., Almaula, N., Inouye S., and Inouye, M. (1993). J. Bacteriol. 175, 1176-1181.
Nickerson, J., and Wells, W. (1984). J. Biol. Chem. 259, 11,297-11,304.
Postel, E. H., and Ferrone, C. A. (1994). J. Biol. Chem. 269, 8627-8630.
Reymond, A., Volorio, S., Merla, G., Al-Maghtheh, M., Zuffardi, O., and Bulfone, Oncogene 18, 7244-7252.
Rosengard, A., Krutzsch, H., Shearn, A., Biggs, J., Barker, E., Margulies, I., Richter-King, C., Liotta, L., and Steeg, P. (1989). Nature (London) 342, 177-180.
Shearn, A., Rice, T., Garen, A., and Gehring, W. (1971). Proc. Natl. Acad. Sci. USA 68, 2294-2598.
Stewart, M., Murphy, C., and Fristrom, J.W. (1972). Develop. Biol. 27, 71-83.
Sturtevant, A. H. (1956). Genetics 41, 118-123.
Teng, D. H., Bender, L. B., Engele, C. M., Tsobuta, S., and Venkatesh, T. (1991a).Genetics 128, 373-380.
Teng, D. H. F., Engele, C. M., and Venkatesh, T. (1991b). Nature (London) 353, 437-440.
Tepper, A. D., Dammann, H., Bominaar, A. A., and Veron, M. (1994). J. Biol. Chem. 269, 1-6.
Timmons, L., and Shearn, A. (1996). Genetics 144, 1589-1600.
Timmons, L., and Shearn, A. (1997). Advan. Genet. 35, 207-252.
Timmons, L., Hersperger, E., Woodhouse, E., Xu, J., Liu, L.-Z., and Shearn, A. (1993). Develop. Biol. 156, 364-379.
Timmons, L., Xu, J., Hersperger, G., Deng, X.-F., Tharakan, M., and Shearn, A. (1995). J. Biol. Chem. 270, 23021-23030.
Wallet, V., Mutzel, R., Troll, H., Barzu, O., Wurster, B., Veron, M., and Lacombe, M. (1990). J. Natl. Can. Inst. 82, 1199-1202.
Wieland, T., and Jakobs, K. H. (1992). Mol. Pharmacol. 42, 731-735.
Williams, R. L., Oren, D. A., Munoz-Dorado, J., Inouye, S., Inouye, M., and Arnold, E. (1993). J. Mol. Biol. 234, 1230-1247.
Xu, J., Liu, L.-Z., Deng, X.-F., Timmons, L., Hersperger, E., Steeg, P. S., Veron, M., and Shearn, A. (1996). Develop. Biol. 177, 544-557.
Zinyk, D. L., McGonnigal, B., and Dearolf, C. R. (1993). Nature Genet. 4, 195-201.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Timmons, L., Shearn, A. Role of AWD/Nucleoside Diphosphate Kinase in Drosophila Development. J Bioenerg Biomembr 32, 293–300 (2000). https://doi.org/10.1023/A:1005545214937
Issue Date:
DOI: https://doi.org/10.1023/A:1005545214937