Summary
The antitumor activity of Carbetimer was tested against 171 patient's tumors in a human tumor cloning system. Sixty-seven tumor specimens had adequate growth to be considered evaluable. In 21 specimens survival of tumor colony forming units was ≤50% that in control plates. Antitumor effect was most impressive in carcinomas of the breast, ovary, and lung. This information will be useful in planning disease oriented Phase II trials.
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Kisner, D.L., Mehta, P., Paget, G.E. et al. Activity of Carbetimer in a human tumor cloning system. Invest New Drugs 2, 55–58 (1984). https://doi.org/10.1007/BF00173787
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DOI: https://doi.org/10.1007/BF00173787