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Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster

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Abstract

A glucose oxidase (GO) has been identified in the ejaculatory duct of male Drosophila melanogaster. Evidence is given that this enzyme was previously misidentified as HEX-1. Genetic analysis indicates that the Go structural gene is located on the third chromosome at 48 ± 0.5 cm. Go is polymorphic in males in populations of D. melanogaster and D. simulans located in Athens, Georgia. Two other hexose enzymes have also been tentatively identified for the first time in Drosophila. These are NAD(P)-glucose dehydrogenase (GODH) and NAD-gluconate dehydrogenase (GNDH). GODH and GNDH are found in both males and females and may circumvent the initial steps in the pentose shunt.

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Authors and Affiliations

  1. Department of Botany and Department of Molecular and Population Genetics, University of Georgia, 30602, Athens, Georgia

    Douglas R. Cavener

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  1. Douglas R. Cavener
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This work was supported by Grants No. DEB76-82479 and DEB-7900822 from the National Science Foundation to M. T. Clegg and by Training Grant 5-732-GM07103-04 of the National Institutes of Health.

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Cavener, D.R. Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster . Biochem Genet 18, 929–937 (1980). https://doi.org/10.1007/BF00500125

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  • DOI: https://doi.org/10.1007/BF00500125

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