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The vγ chain of fetal hemoglobin of the orangutan

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Abstract

Previous studies suggested that orangutans have nonallelic structural genes for their γ chains, because either a threonyl or an alanyl residue may occupy position 135. Further investigation has now detected that position 75 may have either an isoleucyl or a valyl residue. From available evidence, the isoleucyl and threonyl residues are in one chain and the valyl and alanyl in the other. Orangutans appear to be homozygous for the two types of nonallelic genes.

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References

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Authors and Affiliations

  1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 91125, Pasadena, California

    W. A. Schroeder, J. Roger Shelton & Joan B. Shelton

  2. Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, 30902, Augusta, Georgia

    T. H. J. Huisman

Authors
  1. W. A. Schroeder
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  2. J. Roger Shelton
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  3. Joan B. Shelton
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  4. T. H. J. Huisman
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Additional information

These studies were supported in part by grants (HL-02558 and HL-05168) from the National Institutes of Health, U.S. Public Health Service. This is Contribution No. 5740 from the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California.

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Schroeder, W.A., Shelton, J.R., Shelton, J.B. et al. The vγ chain of fetal hemoglobin of the orangutan. Biochem Genet 16, 1203–1205 (1978). https://doi.org/10.1007/BF00484540

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  • DOI: https://doi.org/10.1007/BF00484540

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