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Changes in the antinociceptive effect of mesencephalic stimulation produced by analgesics and tranquilizers

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Chronic experiments on cats showed that analgesics, in subanalgesic doses, not only exhibit an antinociceptive effect when accompanied by subthreshold stimulation of the mesencephalon, but also potentiate the analgesic action of central stimulation. Tranquilizers only facilitate the development of an analgesic effect during subthreshold mesencephalic stimulation. The possible reasons for differences in the action of these substances are discussed.

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Authors
  1. A. V. Dmitriev
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  2. Yu. D. Ignatov
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Dmitriev, A.V., Ignatov, Y.D. Changes in the antinociceptive effect of mesencephalic stimulation produced by analgesics and tranquilizers. Bull Exp Biol Med 85, 42–46 (1978). https://doi.org/10.1007/BF00801452

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  • DOI: https://doi.org/10.1007/BF00801452

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