The dynamics of the change in complement titer in guinea pigs during anaphylactic shock and under conditions of inhibition of the shock with dimedrol

Summary

In guinea pigs with anaphylactic shock, provoked by injection of specific antigen, the complement titer usually dropped in one hour after its administration, the reduction being maximal in 3–4 hours. In the majority of animals, the complement level was restored in 24 hours after the shock. Preliminary administration of dimedrol prevented the anaphylactic shock and maintained the complement at the initial level in the guinea pigs.