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Effect of the dose of dexamethasone and cell population composition on thein Vitro production of tumor necrosis factor and interleukin-6 by human peripheral blood mononuclears

  • Oncology
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Abstract

In vitro experiments demonstrate that various doses of dexamethasone not only inhibit production of interleukin-6 and tumor necrosis factor but also markedly stimulate it in cells of the total pool of human peripheral blood mononuclears. Production of tumor necrosis factor in the presence of dexamethasone is stimulated in all donors, while production of interleukin-6 is strongly inhibited, usually in a dose-dependent manner.

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Authors and Affiliations

  1. Medico—Genetic Research Center, Russia Academy of Medical Sciences, Moscow

    E. A. Kalashnikova, A. L. Pukhal'skii & S. V. Khaidukov

  2. M. M. Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow

    E. A. Kalashnikova, A. L. Pukhal'skii & S. V. Khaidukov

Authors
  1. E. A. Kalashnikova
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  2. A. L. Pukhal'skii
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  3. S. V. Khaidukov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 667–672, June, 1996

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Kalashnikova, E.A., Pukhal'skii, A.L. & Khaidukov, S.V. Effect of the dose of dexamethasone and cell population composition on thein Vitro production of tumor necrosis factor and interleukin-6 by human peripheral blood mononuclears. Bull Exp Biol Med 121, 602–606 (1996). https://doi.org/10.1007/BF02447130

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  • DOI: https://doi.org/10.1007/BF02447130

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