Summary
The effect of adding the defect-forming molecules melittin and C12E5 to DMPC membranes has been studied and the corresponding phase diagrams established. Light, X-ray and neutron small-angle scattering have been used to characterize the mixed membranes. Both systems show a melting of the lamellar Lα into an isotropic phase upon addition of the second membrane constituent. The molar ratio, where the melting occurs is the same in concentrated and dilute samples. For the DMPC/C12E5 system not only membrane composition, but also temperature can be used to induce a transition from an isotropic to a lamellar phase.
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König, S., Méléard, P. & Roux, D. A comparison of DMPC membranes mixed with melittin or C12E5 . Nouv Cim D 16, 1585–1594 (1994). https://doi.org/10.1007/BF02462046
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DOI: https://doi.org/10.1007/BF02462046