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Biologische beschikbaarheid van orale amoxicillinepreparaten

Bioavailabilily of oral amoxicillin preparations

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Abstract

Absorption of amoxicillin was measured in healthy volunteers after oral administration of various capsules and suspensions of two brands. Absorption from suspension is faster and more complete than from capsules. There is a large variation in absorption between volunteers.

Samenvatting

Bij gezonde vrijwilligers werd de resorptie van amoxicilline bepaald na orale toediening van verschillende capsules en suspensies van twee handelspreparaten. De resorptie uit suspensie is sneller en vollediger dan uit capsules. Tussen vrijwilligers bestaat een grote variatie in resorptie.

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Author information

Authors and Affiliations

  1. Afdeling Klinische Farmacologie, Farmacologie, Academisch Ziekenhuis, Rijnsburgerweg 10, 2333 aa, Leiden

    H. Mattie

  2. Arts, Concern Stafafdeling Medische Aangelegenheden, Gist-Brocades nv, Delft

    J. W. Bins

  3. Vakgroep Medische Statistiek en Informatieverwerking,Medische Faculteit, Rijksuniversiteit Leiden, Netherlands

    J. Hermans

Authors
  1. H. Mattie
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  2. J. W. Bins
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  3. J. Hermans
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Mattie, H., Bins, J.W. & Hermans, J. Biologische beschikbaarheid van orale amoxicillinepreparaten. Pharmaceutisch Weekblad Scientific Edition 2, 1017–1020 (1980). https://doi.org/10.1007/BF02273254

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  • DOI: https://doi.org/10.1007/BF02273254

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