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High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man

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Abstract

A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, < 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, University Hospital Nijmegen Saint Radboud, P.O. Box 9101, 6500, HB Nijmegen, the Netherlands

    T. B. Vree, E. W. J. Beneken Kolmer &  Y. A. Hekster

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  1. T. B. Vree
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  2. E. W. J. Beneken Kolmer
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  3. Y. A. Hekster
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Vree, T.B., Beneken Kolmer, E.W.J. & Hekster, Y.A. High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man. Pharmaceutisch Weekblad Scientific Edition 12, 243–246 (1990). https://doi.org/10.1007/BF01967825

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