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Kompressionsverhalten isotroper Pulvermischungen

Compression-properties of isotropic powder mixtures

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Abstract

The three hyperbolic constants a, b and C were interpreted for the compression equation (s − a) (p + b) = C. Their dependence upon the mixture ratio of two substances was investigated. The quantity b was designated as deformation strain, it can be related to the yield point of a material. The proportion of deformed drug in a tablet formulation can be estimated by means of the constant b.

Zusammenfassung

Für die Kompressionsgleichung (s − a) (p + b) = C wurden die drei Hyperbelkonstanten a, b, und C interpretiert und ihre Abhängigkeit vom Mischungsverhältnis zweier Substanzen untersucht. Die Grö\e b wurde als Verformungsspannung bezeichnet, sie kann mit der Flie\grenze eines Materials in Beziehung gesetzt werden. In einer Tablettenrezeptur kann der Anteil an verformtem Arzneistoff mit Hilfe der Konstanten b abgeschätzt werden.

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Authors and Affiliations

  1. Institut für Pharmazeutische Technologie der Technischen Universität Braunschweig, Pockelsstra\e 4, D-3300, Braunschweig, Bundesrepublik Deutschland

    C. Führer & M. A. Schmidt

Authors
  1. C. Führer
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  2. M. A. Schmidt
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Hernn ProfessorPolderman aus Anla\ seines Eintritts in den Ruhestand gewidmet.

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Führer, C., Schmidt, M.A. Kompressionsverhalten isotroper Pulvermischungen. Pharmaceutisch Weekblad Scientific Edition 1, 1443–1450 (1979). https://doi.org/10.1007/BF02293483

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  • DOI: https://doi.org/10.1007/BF02293483

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