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Variation in susceptibility to experimental dermatomycosis in genetic strains of mice, III

Some comparisons of the susceptibility of conventional and gnotobiotic lines of the I.C.R. strain to trichophyton mentagrophytes

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Summary

A comparison is made of the results ofTrichophyton mentagrophytes-inoculations onto conventionally-reared and gnotobiotic I.C.R. strain Swiss white mice. It appears that the method of inoculationsite preparation has a decided effect on lesion development, since the mechanical removal of hair with scissors resulted in lesion formation, whereas in the experiments using a surgical depilatory, no lesions were formed.

The preliminary studies on the role of the allergic reaction in dermatomycotic pathogenesis indicate that more than three exposures to inocula which contained approximately 225,000 infective units (spores or mycelial fragments) are necessary for lesions to be produced in gnotobiotes. They also suggest that two such exposures toT. mentagrophytes do not sensitize the animal toMicrosporon gypseum.

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Literature

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Authors and Affiliations

  1. Department of Botany and Plant Pathology Ohio State University, Columbus, Ohio

    J. A. Schmitt Ph. D. & R. G. Miller B. Sc.

Authors
  1. J. A. Schmitt Ph. D.
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  2. R. G. Miller B. Sc.
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Additional information

Paper # 714, Department of Botany and Plant Pathology, Ohio State University, 1735 Neil Avenue, Columbus, Ohio 43210.

The gnotobiote portion of this investigation was done at the O.S.U. Laboratory Animal Facility, RobertD. Henthorne, Director, to whom we express our appreciation for space and technical assistance.

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Schmitt, J.A., Miller, R.G. Variation in susceptibility to experimental dermatomycosis in genetic strains of mice, III. Mycopathologia et Mycologia Applicata 32, 306–312 (1967). https://doi.org/10.1007/BF02202071

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  • DOI: https://doi.org/10.1007/BF02202071

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