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Paracoccidioidomycosis in nude mice: Presence of filamentous forms of the fungus

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Abstract

Congenitally athymic nude mice (nu/nu) and their phenotypically normal littermates (nu/+) were intraperitoneally infected with yeast cells of a strain of Paracoccidioides brasiliensis. The nude mice developed a severe and generalized infection with an intense parasitism of several organs, accompanied by a low-grade of tissue reaction. The lesions were characterized by abundant yeast-like cells of the fungus, and in some animals, numerous hyphal forms could be well visualized. In control animals, infection was moderate, almost exclusively restricted to the area of inoculation, and the lesions presented few parasites surrounded by an inflammatory response. Filamentous forms of the fungus were never encountered in these animals.

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Authors and Affiliations

  1. Department of Pathology, Instituto Oswaldo Cruz, C.P. 926, Rio de Janeiro, Brasil

    I. B. Kerr

  2. Department of Mycology, Instituto Oswaldo Cruz, C.P. 926, Rio de Janeiro, Brasil

    A. M. Mendes da Silva & P. de Oliveira

  3. Unité de Mycologie, Institut Pasteur, Paris, France

    E. Drouhet

  4. Department of Protozoology, Instituto Oswaldo Cruz, C.P. 926, Rio de Janeiro, Brasil

    S. C. G. da Costa

Authors
  1. I. B. Kerr
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  2. A. M. Mendes da Silva
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  3. E. Drouhet
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  4. P. de Oliveira
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  5. S. C. G. da Costa
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Kerr, I.B., Mendes da Silva, A.M., Drouhet, E. et al. Paracoccidioidomycosis in nude mice: Presence of filamentous forms of the fungus. Mycopathologia 101, 3–11 (1988). https://doi.org/10.1007/BF00455663

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