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Production of trichothecene and non-trichothecene mycotoxins by Fusarium species isolated from maize in Minnesota

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Abstract

Eighty-two cultures of Fusarium species isolated in 1986 from moldy maize in Minnesota were each cultured on rice for 4 weeks and found to produce the following mycotoxins: F. graminearum isolates, deoxynivalenol (DON, 4–225 μg/g), 3-acetyldeoxynivalenol (3-ADON, 2–4μg/g), 15-acetyldeoxynivalenol (15-ADON, 1–35 μg/g) and zearalenone (ZEA, 5–4350 μg/g); F. moniliforme, fusarin C (detectable amounts to 1000 μg/g); F. mòniliforme, F. oxysporum, F. proliferatum and F. subglutinans isolates, moniliformin (15–6775 μg/g); F. moniliforme, F. proliferatum, and F. subglutinans isolates, fusaric acid (detectable amounts). Other mycotoxins screened for in each rice sample and not detected were T-2 toxin, HT-2 toxin, neosolaniol, T-2 tetraol, nivalenol, fusarenon-X, scirpenols, alpha and beta trans-zearalenols, wortmannin, and fusarochromanone. The rat feeding bioassay indicated that other, unidentified toxins may be present.

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References

  1. Abbas HK, Mirocha CJ. Production of fusarenon-X, nivalenol and zearalenone by Gibberella zeae isolates and their toxicity in fibroblasts and rats. Mycotoxin Res 1988; 4: 67–74.

    Google Scholar 

  2. Abbas HK, Mirocha CJ. Isolation and purification of a hemorrhagic factor (wortmannin) from Fusarium oxysporum N17B. Appl Environ Microbiol 1988; 54: 1268–1274.

    Google Scholar 

  3. Abbas HK, Mirocha CJ, Kommedahl T, Burnes PM, Meronuck RA, Gunther R. Toxigenicity of Fusarium proliferatum and other Fusarium species isolated from corn ears in Minnesota. Phytopathology 1988; 78: 1258–1260.

    Google Scholar 

  4. Abbas HK, Mirocha CJ, Meronuck RA, Pokorny JD, Gould SL, Kommedahl T. Mycotoxins and Fusarium species associated with infected ears of corn in Minnesota. Appl Environ Microbiol 1988; 54: 1930–1933.

    Google Scholar 

  5. Abbas HK, Mirocha CJ, Shier WT. Mycotoxins produced from fungi isolated from foodstuffs and soil: comparison of toxicity in fibroblasts and rat feeding tests. Appl Environ Microbiol 1984; 48: 654–661.

    Google Scholar 

  6. Abbas HK, Mirocha CJ, Tuite J. Natural occurrence of deoxynivalenol, 15-acetyldeoxynivalenol, and zearalenone in refusal factor corn stored since 1972. Appl Environ Microbiol 1986; 51: 841–843.

    Google Scholar 

  7. Allen NK, Burmeister HR, Weaver GA, Mirocha CJ. Toxicity of dietary and intravenously administered moniliformin to broiler chickens. Poult Sci 1981; 60: 1415–1417.

    Google Scholar 

  8. Burmeister HR, Ciegler A, Vesonder RF. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl Environ Microbiol 1979; 37: 11–13.

    Google Scholar 

  9. Burmeister HR, Grove MD, Kwolek WF. Moniliformin and butenolide: effect on mice of high-level, long-term oral intake. Appl Environ Microbiol 1980; 40: 1142–1144.

    Google Scholar 

  10. Cole M, Reynolds JD, Vesonder RF, Buck WB, Swanson SP, Coffey T, Brown CD. Survey of vomitoxin-contaminated feed grains in midwestern United States and associated health problems in swine. J Amer Vet Med Assn 1984; 184: 189–192.

    Google Scholar 

  11. Forsell JH, Jensen R, Tal JH, Witt M, Lin WS, Pestka JJ. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F mouse after dietary exposure to 15-acetyldeoxynivalenol. Fd Chem Toxic 1987; 24: 1309–1313.

    Google Scholar 

  12. Gelderblom WCA, Thiel PG, Marasas WFO, van der Merve KJ. Natural occurrence of fusarin C on mutagen produced by Fusarium moniliforme in corn. J Agric Food Chem 1984; 32: 1064–1067.

    Google Scholar 

  13. Golinski P, Vesonder RF, Latus-Zietkiewicz D, Perkowski J. Formation of fusarenone-X, nivalenol, zeararalenone, a-trans-zearalenol, b-trans zearalenol and fusarin C by Fusarium crookwellense. Appl Environ Microbiol 1988; 54: 2147–2148.

    Google Scholar 

  14. Mirocha CJ. Mycotoxicosis associated with Fusarium. In: Moss MO, Smith JE, eds. The Applied Mycology of Fusarium, Cambridge University Press, Cambridge, England, 1984; 141–155.

    Google Scholar 

  15. Mirocha CJ, Abbas HK, Windeis CE, Xie W. Variation in deoxynivalenol, 15-acetyl-DON, 3-acetyl-DON and zearalenone production by Fusarium graminearum isolates. Appl Environ Microbiol 1989; 55: 1315–1316.

    Google Scholar 

  16. Mirocha CJ, Christensen CM, Nelson GH. F-2 (zearalenone) estrogenic mycotoxin from Fusarium. In: Kadis S, Ciegler A, Aji SJ, eds. Microbial Toxins, Volume 7. Academic Press, New York, 107–138, 1971.

    Google Scholar 

  17. Pathre SV, Gleason WB, Lee YW, Mirocha CJ. The structure of fusarochromanone: new mycotoxin from Fusarium roseum ‘graminearum’. Can J Chem 1986; 64: 1308–1311.

    Google Scholar 

  18. Pestka JJ, Lin WS, Forsell JH. Decreased feed consumption and body-weight gain in the B6C3F1 mouse after dietary exposure to 15-acetyldeoxynivalenol. Fd Chem Tox 1986; 24: 1309–1313.

    Google Scholar 

  19. Pier AC, Richard JL, Cysewski SJ. Implications of mycotoxins in animal disease. J Amer Vet Med Assn 1980; 176: 719–724.

    Google Scholar 

  20. Schiefer HB, Nicholson S, Kasali OB, Hancock DS, Greenhalgh R. Pathology of acute 3-acetyldeoxynivalenol toxicity in mice. Can J Comp Med 1985; 49: 315–318.

    Google Scholar 

  21. Scott PM, Lawrence GA. Liquid chromatographic determination and stability of the Fusarium mycotoxin moniliformin in cereal grains. J Assoc Off Anal Chem 1987; 70: 850–853.

    Google Scholar 

  22. Thiel PG, Gelderblom WCA, Marasas WFO, Nelson PE, Wilson TM. Natural occurrence of moniliformin and fusarin C in corn screenings known to be hepatocarcinogenic in rats. J Agric Food Chem 1986; 34: 773–775.

    Google Scholar 

  23. Thiel PG, Meyer CJ, Marasas WFO. Natural occurrence of moniliformin together with deoxynivalenol and zearalenone in Transkeian corn. J Agric Food Chem 1986; 30: 308–312.

    Google Scholar 

  24. Vesonder RF. Moniliformin produced by cultures of Fusarium moniliformin var. subglutinans isolated from swine feed. Mycopathologia 1986; 95: 149–153.

    Google Scholar 

  25. Weibe LA, Bjeldanes LF. Fusarin C, a mutagen from Fusarium moniliforme on corn. J Food Protection 1981; 46: 1424–1426.

    Google Scholar 

  26. Yoshizawa T, Morooka N. Deoxynivalenol and its monoacetate. New mycotoxins from Fusarium roseum and moldy barley. Agric Biol Chem 1973; 37: 2933–2934.

    Google Scholar 

  27. Yoshizawa T, Shirota T, Morooka N. Toxic substances in infected cereals. VI Deoxynivalenol and its acetate as feed refusal principles in rice cultures with Fusarium roseum no. 117 (ATCC 28114). J. Food Hyg Soc Jpn 1978; 19: 178–184.

    Google Scholar 

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Authors and Affiliations

  1. Department of Plant Pathology, University of Minnesota, 55108, St. Paul, MN, USA

    H. K. Abbas, C. J. Mirocha & T. Kommedahl

  2. U.S. Department of Agriculture, Agricultural Research Service, Northern Research Center, 61604, Peoria, IL, USA

    R. F. Vesonder

  3. Department of Chemistry, Agricultural University of Poznan, Woljska Polskiego, Poznan, Poland

    P. Golinski

Authors
  1. H. K. Abbas
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  2. C. J. Mirocha
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  3. T. Kommedahl
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  4. R. F. Vesonder
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  5. P. Golinski
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Abbas, H.K., Mirocha, C.J., Kommedahl, T. et al. Production of trichothecene and non-trichothecene mycotoxins by Fusarium species isolated from maize in Minnesota. Mycopathologia 108, 55–58 (1989). https://doi.org/10.1007/BF00436784

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