Abstract
We have synthesized by solution methods and fully characterizedtwo sets of terminally protected peptides based on the tricyclic Cα α-disubstituted glycine Afc. Theconformational preferences of the Afc/Gly peptides were examined by FT-IR absorption and 1H NMR techniques, whilethose of the Afc/TOAC peptides were primarily investigated by using fluorescence spectroscopy. The X-ray diffraction structure of an Afc derivative was also analyzed. The body of solution and crystal-state experimental data conclusively confirms previous findings that the Afc residue may either adopt the fully extended (C5) or a turn conformation.
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Crisma, M., Formaggio, F., Mezzato, S. et al. Afc can adopt either the fully extended or a turn conformation. Letters in Peptide Science 7, 123–131 (2000). https://doi.org/10.1023/A:1008915732443
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DOI: https://doi.org/10.1023/A:1008915732443