Abstract
Novel endomorphin-2 analogs containing the unusual amphiphilic amino acid (R)- and (S)-α-hydroxymethyltyrosine in position 1 and (R)- and (S)-α-hydroxymethylphenylalanine in the positions 3 and 4 were synthesized via the solid-phase method. The binding characteristics of the synthetic analogs may suggest that α-hydroxymethyl substitution of aminoacid residues influences the conformation of a peptide much more than simply increasing the local amphiphilic character of the peptide.
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Olma, A., Tourwé, D. Synthesis and binding properties of endomorphin-2analogs containing α-hydroxymethyl amino acids. Letters in Peptide Science 7, 93–96 (2000). https://doi.org/10.1023/A:1008906527082
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DOI: https://doi.org/10.1023/A:1008906527082