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Helix induction potential of N-terminal α-methyl, α-amino acids

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Abstract

A series of longer analogues of the C-peptide of RNAse A has been synthesized with the aim of assessing the helix induction potential in water of α-methyl, α-amino acids at the N-terminus of the chain. The circular dichroism data indicate that one isovaline residue is effective in increasing the helix content of the 13-residue peptide by about 7%.

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Authors and Affiliations

  1. Biopolymer Research Centre, CNR, Department of Organic Chemistry, University of Padova, Via Marzolo 1, I-35131, Padova, Italy

    Marina Gobbo, Laura Biondi, Fernando Filira, Fernando Formaggio, Marco Crisma, Raniero Rocchi & Claudio Toniolo

  2. DSM Research, Organic Chemistry and Biotechnology Section, P.O. Box 18, 6160, MD, Geleen, The Netherlands

    Quirinus B. Broxterman

  3. DSM Fine Chemicals, 6401, JH, Heerlen, The Netherlands

    Johan Kamphuis

Authors
  1. Marina Gobbo
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  2. Laura Biondi
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  3. Fernando Filira
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  4. Fernando Formaggio
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  5. Marco Crisma
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  6. Raniero Rocchi
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  7. Claudio Toniolo
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  8. Quirinus B. Broxterman
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  9. Johan Kamphuis
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Gobbo, M., Biondi, L., Filira, F. et al. Helix induction potential of N-terminal α-methyl, α-amino acids. Letters in Peptide Science 5, 105–107 (1998). https://doi.org/10.1023/A:1008873910529

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  • DOI: https://doi.org/10.1023/A:1008873910529

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