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Oligocarbamates as MHC class I ligands

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Abstract

New ligands for major histocompatibility complex (MHC) class I molecules were prepared using a flexible automated synthesis of oligocarbamates. An efficient solution-phase synthesis was found for Fmoc-amino alcohols which are required as building blocks. The biological activity of the oligomeric peptidomimetics was demonstrated in a stabilizing assay with MHC class I presenting cells.

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References

  1. Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, VCH, Weinheim, 1996, pp. 1–18, 203–246 and 349–362.

    Google Scholar 

  2. Fleckenstein, B., Kalbacher, H., Muller, C.P., Stoll, D., Halder, T., Jung, G. and Wiesmüller, K.-H., Eur. J. Biochem., 240 (1996) 71.

    PubMed  Google Scholar 

  3. Cho, C.Y., Morna, E.J., Cherry, S.R., Stephans, J.C., Fodor, S.P.A., Adams, C.L., Sundaran, A., Jacobs, J.W. and Schultz, P.G., Science, 261 (1993) 1303.

    PubMed  Google Scholar 

  4. Udaka, K., Wiesmüller, K.-H., Kienle, S., Jung, G. and Walden, P., J. Exp. Med., 181 (1995) 2097.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut für Organische Chemie, Auf der Morgenstelle 18, D-72076, Tübingen, Germany

    Ralf Warrass & Günther Jung

  2. Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, D-72762, Reutlingen, Germany

    Ralf Warrass & Karl-Heinz Wiesmüller

  3. Dermatologische Klinik, Charité, Humboldt-Universität zu Berlin, D-10117, Berlin, Germany

    Peter Walden

Authors
  1. Ralf Warrass
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  2. Peter Walden
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  3. Karl-Heinz Wiesmüller
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  4. Günther Jung
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Warrass, R., Walden, P., Wiesmüller, KH. et al. Oligocarbamates as MHC class I ligands. Letters in Peptide Science 5, 125–128 (1998). https://doi.org/10.1023/A:1008821817913

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  • DOI: https://doi.org/10.1023/A:1008821817913

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