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Macrocyclic lactones as a source for radiohalogenated fatty acid analogs and their precursors

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Abstract

A simple approach is presented whereby omega halogenated fatty acids can be obtained from macrocyclic musk lactones which are industrially available. While providing a secure source of 16-iodo-hexadecanoic acid and 17-iodo-heptadecanoic acid, the scheme allows ready access to a large number of untried fatty acid analogs. Examples presented are 16-iodo-hexadecanoic acid. 16-iodo-7-hexadecenoic acid. 16-iodo-12-oxa-hexadecanoic acid, 15-iodo-pentadecanoic acid, and 15-iodo-12-keto-pentadecanoic acid.

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Authors and Affiliations

  1. TRIUMF, University of British Columbia, Vancouver, B. C., (Canada)

    H. Dougan & J. S. Vincent

  2. Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B. C., (Canada)

    D. M. Lyster

Authors
  1. H. Dougan
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  2. D. M. Lyster
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  3. J. S. Vincent
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Dougan, H., Lyster, D.M. & Vincent, J.S. Macrocyclic lactones as a source for radiohalogenated fatty acid analogs and their precursors. Journal of Radioanalytical and Nuclear Chemistry, Articles 89, 71–78 (1985). https://doi.org/10.1007/BF02070205

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  • DOI: https://doi.org/10.1007/BF02070205

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