Abstract
As part of an examination of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of platinum and biologically essential trace elements of tumour tissue and different organs were determined. The activation analysis procedure — separation of32P, isolation of199Au and99Mo — is described. In the course of a pharmakokinetical experiment with tumourbearing rats (DMBA induced hormone-dependent tumours) the desired enrichment of the administered drug in the tumour tissue was found. Changes of the trace element level of tumour tissue were found for hormone-dependent MXT-mammary tumours on mice.
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Haeberlin, S.T., Lux, F., Karl, J. et al. Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing32P as well as for the estimation of99 Mo and199Au. Journal of Radioanalytical and Nuclear Chemistry, Articles 113, 461–467 (1987). https://doi.org/10.1007/BF02050521
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DOI: https://doi.org/10.1007/BF02050521