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X-ray structure and thermal analysis of a 1∶1 complex between (S)-naproxen and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin

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Abstract

An inclusion complex between TRIMEB and (S)-naproxen has been crystallised and characterised by physicochemical methods including X-ray analysis. The complex crystallises in the orthorhombic crystal system, space groupP212121, witha=15.179(4),b=21.407(5),c=27.67(1) Å andZ=4. The structure was solved using published coordinates for the skeleton atoms of TRIMEB in an isomorphous complex. Refinement by full-matrix least-squares analysis yieldedR=0.0571 for 6573 unique observed reflections. Hydrophobic forces are responsible for the inclusion of the drug, which has its methoxy group buried in the cavity of the host and its propionic acid moiety protruding from the O(2), O(3) side of the TRIMEB molecule. Both host and guest undergo conformational changes on complexation relative to their conformations observed in the TRIMEB monohydrate and naproxen crystal structures respectively. Complex units pack in a screw-channel mode in a head-to-tail fashion with their axes almost parallel to theb-axis.

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Caira, M.R., Griffith, V.J., Nassimbeni, L.R. et al. X-ray structure and thermal analysis of a 1∶1 complex between (S)-naproxen and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin. J Incl Phenom Macrocycl Chem 20, 277–290 (1994). https://doi.org/10.1007/BF00708773

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  • DOI: https://doi.org/10.1007/BF00708773

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