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An approach to channel type molecular structures. 1. Synthesis ofBouquet-shaped molecules based on an [18]-O6 polyether macrocycle

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Abstract

An approach to a transmembrane cation channel is described. It is based on the grafting of oxygen bearing side-chains on a macrocyclic polyether unit that constitutes the organizing core. The resulting species has a structure of overall bouquet shape. The synthesis of such a molecule .ℬ 0M ,14a is described, together with that of its analogue bearing polymethylene side-chains ℬ CM ,14b. The physicochemical properties of these molecules indicate that they possess the features expected on the basis of their structure.

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Authors and Affiliations

  1. Laboratoire de Chimie des Interactions Moléculaires, Collège de France, 11, Place Marcelin Berthelot, F-75005, Paris, France

    Ludovic Jullien & Jean-Marie Lehn

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  1. Ludovic Jullien
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  2. Jean-Marie Lehn
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This paper is dedicated to the memory of the late Dr C. J. Pedersen.

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Jullien, L., Lehn, JM. An approach to channel type molecular structures. 1. Synthesis ofBouquet-shaped molecules based on an [18]-O6 polyether macrocycle. J Incl Phenom Macrocycl Chem 12, 55–74 (1992). https://doi.org/10.1007/BF01053855

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  • DOI: https://doi.org/10.1007/BF01053855

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