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Towards an identification of the pyrethroid pharmacophore. A molecular modelling study of some pyrethroid esters

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Summary

A molecular modelling and computer graphics study of a series of pyrethroid insecticides has been carried out. The three-dimensional arrangement of the groups essential for the biological activity (pharmacophore) has been identified for the acid and the alcohol moieties, respectively. These pharmacophores are based on the relationship between molecular structure and biological activity for a number of pyrethroid esters. The pharmacophores, which describe the relative location in space of the unsaturated systems, the dimethyl groups and the ester moiety, may be useful in the design of novel compounds with pyrethroid activity.

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Authors and Affiliations

  1. Department of Chemistry BC, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark

    Jette R. Byberg & Flemming S. Jørgensen

  2. Research Department, A/S Cheminova, P.O. Box 9, DK-7620, Lemvig, Denmark

    Per D. Klemmensen

Authors
  1. Jette R. Byberg
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  2. Flemming S. Jørgensen
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  3. Per D. Klemmensen
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Byberg, J.R., Jørgensen, F.S. & Klemmensen, P.D. Towards an identification of the pyrethroid pharmacophore. A molecular modelling study of some pyrethroid esters. J Computer-Aided Mol Des 1, 181–195 (1987). https://doi.org/10.1007/BF01677043

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  • DOI: https://doi.org/10.1007/BF01677043

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