References
Avise, J.C. & J.F. McDonald (1976). Enzyme changes during development of holo-and hemi-metabolic insects. J. comp. Biochem. Physiol. 53B: 393–397.
Ayala, F.J., J.R. Powell, M.L. Tracey, C.A. Mourão & S. Pérez-Salas (1972). Enzyme variability in the Drosophila willistoni group. IV. Genic variation in natural populations of Drosophila willistoni. Genetics 70: 113–139.
Bernsteins, S.C., L.H. Throckmorton & J.L. Hubby (1973). Still more genetic variability in natural populations. Proc. natn. Acad. Sci. U.S.A. 70: 3928–3931.
Briscoe, D.A., A. Robertson & J. Malpica (1975). Dominance at the Adh locus in response of adult Drosophila melanogaster to environmental alcohol. Nature 255: 148–149.
Britten, R. & E. Davidson (1969). Gene regulation for higher cells: a theory. Science 165: 349–357.
Britten, R. & E. Davidson (1971). Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty. Q. Rev. Biol. 46: 111–138.
Brown, M.J. (1934). Alcohol-tolerance of Drosophila: an instance of adaptation to an environment lethal to most organisms. J. Hered. 25: 244–246.
David, J. & C. Bocquet (1977). Genetic tolerance to ethanol in Drosophila melanogaster: Increase by selection and analysis of correlated responses. Genetica 47: 43–48.
Day, T.H., P. Hillier & B. Clarke (1974). The relative quantities and catalytic activities of enzymes produced by alleles at the alcohol dehydrogenase locus in Drosophila melanogaster. Biochem. Genetics 11: 155–165.
Day, T.H. & L. Needham (1974). Properties of alcohol dehydrogenase isozymes in a strain of Drosophila melanogaster homozygous for the Adh-slow allele. Biochem. Genet. 11: 167–175.
Dobzhansky, Th., F.J. Ayala, G.L. Stebbins & J.W. Valentine (1977), Evolution, W.H. Freeman, San Francisco, xiv + 572 pages.
Falconer, D.S. (1960). Introduction to Quantitative Genetics, Oliver and Boyd, Edinburgh and London, vi + 365 pages.
Grell, E.H. (1969). Induction of duplications of genes which specify enzymes in Drosophila melanogaster. Genetics 61s: 23 (abstract).
Laurell, C. (1966). Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Analyt. Biochem. 15: 45–52.
Lerner, S.A., T.T. Wu & E.C.C. Lin (1964). Evolution of a catabolic pathway in bacteria. Science 146: 1313–1315.
Lin, E.C.C., A.J. Hacking & J. Aguilar (1976). Experimental models of acquisitive evolution. Bioscience 26: 548–555.
Lindsley, D. & E. Grell (1967). Genetic variations of Drosophila melanogaster. Publs Carnegie Inst. 627.
MacIntyre, R. & S. O'Brien (1976). Interacting gene-enzyme systems in Drosophila. A. Rev. Genet. 10: 281–318.
McClintock, B. (1965). The control of gene action in maize. Brookhaven Symp. Biol. 18: 162–181.
McDonald, J.F. & J.C. Avise (1976). Evidence for the adaptive significance of enzyme activity levels: Interspecific variation in α-GPDH and ADH in Drosophila. Biochem. Genet. 14: 347–355.
McDonald, F.J. & F.J. Ayala (1978). Genetic and biochemical basis of enzyme activity variation in natural populations. I. Alcohol dehydrogenase in Drosophila melanogaster. Genetics 89: 371–388.
McDonald, J.F., G.K. Chambers, J. David & F.J. Ayala (1977). Adaptive response due to changes in gene regulation: A study with Drosophila. Proc. natn. Acad. Sci. U.S.A. 74: 4562–4566.
McKenzie, J.A. & P.A. Parsons (1972). Alcohol tolerance: an ecological parameter in the relative success of Drosophila melanogaster and Drosophila simulans. Oecologia 10: 373–388.
McKenzie, J.A. & P.A. Parsons (1975). Microdifferentiation in a natural population of Drosophila melanogaster to alcohol in the environment. Genetics 77: 385–394.
Milkman, R. (1976). Further evidence of thermostability variation within electrophoretic mobility classes of enzymes. Biochem. Genet. 14: 383–387.
Nelsen, R., J. Lehman & R. Metzenberg (1976). Regulation of phosphate metabolism in Neurospora crassa: Identification of the structural gene for repressible acid phosphatase. Genetics 84: 183–192.
Pipkin, S. & N. Hewitt (1972), Variation of alcohol dehydrogenase levels in Drosophila species hybrids. J. Hered. 63: 267–270.
Stein, G. & J. Stein (1976). Chromosomal proteins: their role in the regulation of gene expression. Bioscience 26: 488–498.
Valentine, J.W. & C.A. Campbell (1975). Genetic regulation and the fossil record. Am. Scient. 63: 673–680.
Vigue, C. & F. Johnson (1973). Isozyme variability in species of the genus Drosophila. VI. Frequency-property-environment relationships of allelic alcohol dehydrogenases in D. melanogaster. Biochem. Genet. 9: 213–227.
Ward, R. (1975). Alcohol dehydrogenase in Drosophila melanogaster: a quantitative character. Genet. Res. 26: 81–93.
Ward, R. & P. Hebert (1972). Variability of alcohol dehydrogenase activity in a natural population of Drosophila melanogaster. Nature New Biol. 236: 243–244.
Wilson, A.C. (1976). Gene regulation in evolution. In: Molecular Evolution, F.J. Ayala (ed.), Sinauer Associates, Massachusetts.
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Ayala, F.J., McDonald, J.F. Continuous variation: Possible role of regulatory genes. Genetica 52, 1–15 (1980). https://doi.org/10.1007/BF00121808
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DOI: https://doi.org/10.1007/BF00121808