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Investigations into the development of the pituitary gland-thyroid tissue axis and distribution of tissue thyroid hormone content in embryonic coho salmon (Oncorhynchus kisutch) from Lake Ontario

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Abstract

Total organism content of L-thyroxine (T4) and triiodo-L-thyronine (T3) were measured in the early developmental stages of a stock of Lake Ontario coho salmon from the egg to the yolk absorption stage. Whole organism T4 levels were constant between the egg and pre-hatch embryo stages, but fell progressively during yolk absorption. T3 levels were low from egg to eye-pigment appearance, but then increased prior to hatch and fell again during the post-hatch yolk absorption period.

When expressed as ng/tissue, T4 content of the body compartment rose progressively between days 67 and 87 post-fertilization, whilst T4 content of the yolk compartment fell progressively during the same period; the pattern was not evident for tissue T3 content. When expressed as ng/g dry weight of tissue, the inverse relationship was found for T4, and T3 content of the body and yolk compartments decreased progressively and increased progressively, respectively during the same period, suggesting that thyroid hormones were selectively retained in the yolk compartment.

Intensely “immunostained” (using anti-human β-TSH antibody) thyrotropic cells were present in small numbers in the pars distalis of the embryonic pituitary at the eye-pigment appearance stage, and the numbers increased markedly until the pre-hatch period.

Administration of either bovine thyrotropic hormone (bTSH) or ovine growth hormone (oGH) had no effect on thyroid hormone content of larvae challenged during the yolk absorption period, suggesting that the thyroid tissue was not responsive to exogenous bTSH challenge at this time, and that oGH-sensitive 5′-monodeiodination was either not present or at levels that were too low to cause an elevation in total T3 content, or that the substrate levels were insufficient to permit a measureable increase in whole body T3 content.

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References cited

  • Ayson, F.G. and Lam, T.J. 1992. Thyroxine injection of female rabbitfish (Siganus guttatus) broodstock; changes in thyroid hormone levels in plasma, eggs, and yolk-sac larvae, and its effect on larval growth and survival. Aquaculture 109: 83–93.

    Article  Google Scholar 

  • Brown, C.L., Doroshov, I., Cochran, M. and Bern, H.A. 1989. Enhanced survival in striped bass fingerlings after maternal triiodothyronine treatment. Fish Physiol. Biochem. 7: 295–299.

    CAS  Google Scholar 

  • Brown, C.L., Sullivan, C.V., Bern, H.A. and Dickhoff, W.W. 1987. Occurrence of thyroid hormones in early developmental stages of teleost fish. AM. Fish. Soc. Symp. 2: 144–150.

    Google Scholar 

  • de Jesus, E.G., Hirano, T. and Inui, Y. 1991. Changes in cortisol and thyroid hormone concentrations during early development and metamorphosis in the Japanes flounder,Paralichthys olivaceus. Gen. Comp. Endocrinol. 82: 369–376.

    Article  PubMed  Google Scholar 

  • Eales, J.G., MacLatchy, D.L. and Sweeting, R.M. 1993. Thyroid hormone deiodinase systems in salmonids and their involvement in the regulation of thyroidal status. Fish Physiol. Biochem. 11: 313–321.

    CAS  Google Scholar 

  • Greenblatt, M., Brown, C.L., Lee, M., Dauder, S. and Bern, H.A. 1989. Changes in the thyroid hormone levels in eggs and larvae and in iodide uptake by eggs of coho and chinook salmon,Oncorhynchus kisutch and O. tschawytscha. Fish Physiol. Biochem. 6: 261–278.

    Article  CAS  Google Scholar 

  • Kobuke, L., Specker, J.L. and Bern, H.A. 1987. Thyroxine content of eggs and larvae of coho salmon,Oncorhynchus kisutch. J. Exp. Zool. 242: 89–94.

    Article  CAS  Google Scholar 

  • Kimura, R., Tagawa, M., Tanaka, M. and Hirano, T. 1992. Developmental changes in tissue thyroid hormone levels of red sea bream Pagrus major. Nipp. Suisan Gakk. 58: 975.

    CAS  Google Scholar 

  • Leatherland, J.F. and Farbridge, K.J. 1992. Chronic fasting reduces the response of the thyroid to growth hormone and TSH, and alters the growth hormone-related changes in hepatic 5′-monodeiodinase activity in rainbow trout,Oncorhynchus mykiss. Gen. Comp. Endocrinol. 87: 342–353.

    Article  PubMed  CAS  Google Scholar 

  • Leatherland, J.F. and Lin, L. 1975. Activity of the pituitary gland of embryo and larval stages of coho salmon,Oncorhynchus kisutch. Can. J. Zool. 53: 297–310.

    Article  PubMed  CAS  Google Scholar 

  • Leatherland, J.F., Lin, L., Down, N.E. and Donaldson, E.M. 1989a. Thyroid hormone content of eggs and early developmental stages of five Oncorhynchus species. Can. J. Fish. Aquat. Sci. 46: 2140–2145.

    CAS  Google Scholar 

  • Leatherland, J.F., Lin, L., Down, N.E. and Donaldson, E.M. 1989b. Thyroid hormone content of eggs and early developmental stages of three stocks of goitred coho salmon from the Great Lakes of North America, and a comparison with a stock from British Columbia. Can. J. Fish. Aquat. Sci. 46: 2146–2152.

    Article  CAS  Google Scholar 

  • Leatherland, J.F. and Sonstegard, R.A. 1980. Seasonal changes in thyroid hyperplasia, serum thyroid hormone and lipid concentrations and pituitary gland structure in Lake Ontario coho salmo (Oncorhynchus kisutch Walbaum) and a comparison with coho salmon from Lakes Michigan and Erie. J. Fish Biol. 16: 539–562.

    Article  CAS  Google Scholar 

  • Milne, R.S. and Leatherland, J.F. 1978. Effect of ovine TSH, thiourea, ovine prolactin and bovine growth hormone on plasma thyroxine and tri-iodothyronine levels in rainbow trout,Salmo gairdneri. J. Comp. Physiol. 124: 105–110.

    CAS  Google Scholar 

  • Reddy, P.K., Brown, C.L., Leatherland, J.F. and Lam, T.J. 1992. Role of thyroid hormones in tilapia larvae (Oreochromis mossambicus): II. Changes in the hormones and 5′-monodeiodinase activity during development. Fish Physiol. Biochem. 9: 487–496.

    Article  CAS  Google Scholar 

  • Reddy, P.K. and Lam, T.J. 1992. Role of thyroid hormones in tilapia larvae (Oreochromis mossambicus): I. Effects of the hormones and an antithyroid drug on yolk absorption, growth and development. Fish Physiol. Biochem. 9: 473–485.

    Article  CAS  Google Scholar 

  • Sullivan, C.V., Iwamoto, R.N. and Dickhoff, W.W. 1987. Thyroid hormones in the blood plasma of developing salmon embryos. Gen. Comp. Endocrinol. 65: 337–345.

    Article  PubMed  CAS  Google Scholar 

  • Tagawa, M. and Hirano, T. 1987. Presence of thyroxine in eggs and changes in its content during early development of chum salmon,Oncorhynchus keta. Gen. Comp. Endocrinol. 68: 129–135.

    Article  PubMed  CAS  Google Scholar 

  • Tagawa, M. and Hirano, T. 1990. Changes in tissue and blood concentrations of thyroid hormones in developing chum salmon. Gen. Comp. Endocrinol. 76: 437–443.

    Article  Google Scholar 

  • Tagawa, M. and Hirano, T. 1991. Effects of thyroid hormone deficiency in eggs on early development of the medaka,Oryzias latipes. J. Exp. Zool. 257: 360–366.

    Article  Google Scholar 

  • Tagawa, M., Miwa, S., Inui, Y., de Jesus, E.G. and Hirano, T. 1990. Changes in thyroid hormone concentrations during early development and metamorphosis of the flounder,Paralichthys olivaceus. Zool. Sci. 7: 93–96.

    CAS  Google Scholar 

  • Tagawa, M., Tanaka, M., Matsumoto, S. and Hirano, T. 1990. Thyroid hormones in eggs of various freshwater, marine and diadromous teleosts and their changes during egg development. Fish Physiol. Biochem. 8: 515–520.

    CAS  Google Scholar 

  • White, B.A. and Nicoll, C.S. 1981. Hormonal control of amphibian metamorphosis. In Metamorphosis: A Problem in Developmental Biology. pp. 363–396. Edited by L.I. Gilbert and E. Frieden. Plenum Press, London.

    Google Scholar 

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  1. Institute of Ichthyology, Department of Zoology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada

    J. F. Leatherland & S. B. Barrett

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  1. J. F. Leatherland
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  2. S. B. Barrett
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Leatherland, J.F., Barrett, S.B. Investigations into the development of the pituitary gland-thyroid tissue axis and distribution of tissue thyroid hormone content in embryonic coho salmon (Oncorhynchus kisutch) from Lake Ontario. Fish Physiol Biochem 12, 149–159 (1993). https://doi.org/10.1007/BF00004380

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