Abstract
Cytogenetic studies of the primate Y chromosomes have suggested that extensive rearrangements have occurred during evolution of the great apes. We have usedin situ hybridization to define these rearrangements at the molecular level.pHU-14, a probe including sequences from the sex determining geneSRY, hybridizes close to the early replicating pseudoautosomal segment in a telomeric or subtelomeric position of the Y chromosomes of all great apes. The low copy repeat detected by the probeFr35-II is obviously included in Y chromosomal rearrangements during hominid evolution. These results, combined with previous studies, suggest that the Y chromosome in great apes has a conserved region including the pseudoautosomal region and the testis-determining region. The rest of the Y chromosome has undergone several rearrangements in the different great apes.
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Toder, R., Zeitler, S., Goodfellow, P.N. et al. Comparative mapping ofSRY in the great apes. Chromosome Res 1, 117–120 (1993). https://doi.org/10.1007/BF00710034
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DOI: https://doi.org/10.1007/BF00710034