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Placental alkaline phophatase in benign and malignant endometrium

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Summary

The presence of placental alkaline phosphatase has been demonstrated immunohistochemically using a monoclonal antibody, in frozen sections of human endometrium. The enzyme is present in glandular epithelium, but is found most commonly in the surface epithelial layer throughout the menstrual cycle. It has also been demonstrated in malignant endometrial epithelium in eight out of twelve patients.

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References

  • Barnstable, C. J., Bodmer, W. F., Brown, G., Galfre, G., Milstein, C., Williams, A. F. &Zeigler, A. (1978) Production of monoclonal antibodies to Group A erythrocytes, HLA and other human cell surface antigens. New tools for genetic analysis.Cell 14, 9–20.

    Google Scholar 

  • Cadeau, J. B., Blackstein, M. E. &Malkin, A. (1974) Increased incidence of placenta-like alkaline phosphatase activity in breast and genitourinary cancer.Cancer Res. 34, 729–732.

    Google Scholar 

  • Doellgast, G. J. &Homesley, H. D. (1984) Placental-type alkaline phosphatase in ovarian cancer fluids and tissues.Obstet. Gynec. 63, 324–9.

    Google Scholar 

  • Goldstein, D. J., Blasco, L. &Harris, H. (1980) Placental alkaline phosphatase in non-malignant human cervix.Proc. natn. Acad. Sci. USA 77, 4226–8.

    Google Scholar 

  • Kabat, E. A. &Furth, J. (1940) A histochemical study of the distribution of alkaline phosphatase in various normal and neoplastic tissues.Am. J. Path. 17, 303–18.

    Google Scholar 

  • Keller, J. A., Bush, R. S. &Malkin, A. (1976) Placenta-like alkaline phosphatase in gynecological cancers.Cancer Res. 36, 269–71.

    Google Scholar 

  • Nathanson, L. &Fishman, W. H. (1971) New observations on the Regan isoenzyme of alkaline phosphatase in cancer patients.Cancer 27, 1388–97.

    Google Scholar 

  • Nozawa, S., Ohta, H., Izumi, S., Hayashi, S., Trutsui, F., Kurihara, S. &Watanabe, K. (1980) Heat-stable alkaline phosphatase in the normal female genital organ-with special reference to the histochemical heat-stability and L-phenylalanine inhibition test.Acta histochem. cytochem. 13, 521–30.

    Google Scholar 

  • Nozawa, S., Ohta, H., Izumi, S., Hayashi, S., Trutsui, F., Kurihara, S. &Watanabe, K. (1981) Heat-stable alkaline phosphatase in uterine cancer, with special reference to its histochemical heat-stability and the L-phenylalanine inhibition test.Histochem. J. 13, 941–51.

    Google Scholar 

  • Ohta, H., Nozawa, S., Arai, H., Tjokro, W., Kurihara, S., Komatsu, N., Kimura, T. &Kikuchi, K. (1982) Enzyme cytochemical studies of alkaline phosphatase in endometrial glandular cell and endometrial cancer.J. clin. Microscopy 15, 5–6.

    Google Scholar 

  • Sunderland, C. A., Davies, J. O. &Stirrat, G. M. (1984) Immunohistology of normal and ovarian cancer tissue with a monoclonal antibody to placental alkaline phosphatase.Cancer Res. 44, 4496–502.

    Google Scholar 

  • Van Nagell, J. R., Donaldson, E. S., Hanson, M. B., Gay, E. C. &Pavlik, E. J. (1981) Biochemical markers in the plasma and tumours of patients with gynecologic malignancies.Cancer 48, 495–501.

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Bristol Maternity Hospital, Southwell Street, BS2 8EG, Bristol, UK

    J. O. Davies, G. M. Stirrat & C. A. Sunderland

  2. Radiotherapy Centre, St Michael's Hill, BSB 8BJ, Bristol, UK

    K. Howe

Authors
  1. J. O. Davies
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  2. K. Howe
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  3. G. M. Stirrat
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  4. C. A. Sunderland
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Davies, J.O., Howe, K., Stirrat, G.M. et al. Placental alkaline phophatase in benign and malignant endometrium. Histochem J 17, 605–612 (1985). https://doi.org/10.1007/BF01003200

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  • DOI: https://doi.org/10.1007/BF01003200

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