Abstract
The activity of central integrative brain neurons is associated with the overall assessment of functionally diverse signals of different sensory modalities which converge on these neurons via parallel inputs. Processing this information, these neurons take part in organizing the animal's various actions and in the mechanisms involved in switching from one action to another. Therefore, understanding of the functional characteristics of central brain neurons requires studies in which the dynamics of neuron activity are recorded continuously throughout a sequence of actions performed by an animal. Traditional methods of analyzing neuron activity, such as the construction of postand peristimulus histograms and cross-correlation analysis, are inadequate for this purpose. These methods allow analysis to be applied to neuron spike activity only around each synchronization point. Their use for studies of a developed program of animal actions unavoidably leads to a set of separate histograms providing no information on the dynamics of neuron activity corresponding to continuous behavior. A complex approach to studying the neuronal correlates of behavior is suggested, designed to overcome these difficulties. The method is based on the use of a developed behavioral program with recording of several neurons in parallel, with analysis of neuron activity using a relative time scale based on the duration of each sequentially performed action. Non-traditional methods of processing neuron spike activity were developed for analysis of the resulting data, including construction of relative histograms and multidimensional statistics methods. These approaches allowed us to study the dynamics of neuron activity continuously through all the stages of performance of a behavioral program and obtain data on the involvement of each group of those neurons which were studied in functionally different actions. This methodology was tested using studies of the functional characteristics of striatum neurons in monkeys. Comparable data were obtained on the individual responses of neurons and on the dynamics of their activity at different stages of the animals' performance of a multicomponent behavioral program. This revealed the lack of functional specialization in striatum neurons and different patterns of their involvement in motor and cognitive functions.
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References
S. V. Afanas'ev, B. F. Tolkunov, A. A. Orlov, and E. V. Selezneva, “Collective responses of neostriatum (putamen) neurons during alternative behaviors by monkeys,”Ros. Fiziol. Zh. im. I. M. Sechenova,83, No. 1-2, 19–27 (1997).
I. F. Kalmykov and A. A. Orlov, “A multichannel microelectrode system for prolonged use,”Ros. Fiziol. Zh. im. I. M. Sechenova,80, No. 8, 135–138 (1994).
A. A. Orlov, and B. P. Mochenkov, “Training of monkeys to complex behavioral tasks,”Zh. Vyssh. Nerv. Deyat.,43, No. 5, 869–877 (1993).
A. A. Orlov, V. I. Shefer, and V. P. Mochenkov, “A miniature multichannel micromanipulator for independent movement of microelectrodes in a bundle,”Fiziol. Zh. SSSR,75, No. 9, 1275–1279 (1989).
B. F. Tolkunov, “The question of time in studies of the neuronal correlates of behavior,”Ros. Fiziol. Zh. im. I. M. Sechenova,83, No. 3, 129–133 (1997).
B. F. Tolkunov, A. A. Orlov, S. V. Afanas'ev, and E. V. Seleznev, “Involvement of striatal (putamen) neurons in motor and non-motor fragments of behavior in monkeys,”Ros. Fiziol. Zh. im. I. M. Sechenova,83, No. 1-2, 11–18 (1997).
D. Hubel, “The brain,” in:The Brain [Russian translation], Mir, Moscow (1982).
M. Abeles, H. Bergman, E. Margalit, and E. J. Vaadia, “Spatiotemporal firing patterns in the frontal cortex of behaving monkeys,”J. Neurophysiol.,70, No. 4, 1629–1638 (1993).
J. W. Aldridge, R. J. Anderson, and J. T. Murphy, “Sensorymotor processing in the caudate nucleus and globus pallidum: a single-unit study in behaving primates,”Can. J. Physiol. Pharm.,58, 1192–1201 (1980).
G. E. Alexander and M. D. Crutcher, “Preparation for movement: neural representation of intended direction in the motor areas of the monkey,”J. Neurophysiol.,64, No. 1, 133–150 (1990).
T. Aosaki, M. Kimura, and A. M. Graybiel, “Temporal and spatial characteristics of tonically active neurons of the primate's striatum,”J. Neurophysiol.,73, No. 3, 1234–1252 (1995).
T. Aosaki, H. Tsubokawa, A. Ishida, K. Watanabe, A. M. Graybiel, and M. Kimura, “Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor,”J. Neurosci.,14, No. 6, 3969–3984 (1994).
P. Apicella, E. Legallet, and E. Trouche, “Responses of tonically discharging neurons in monkey striatum to visual stimuli presented under passive conditions and during task performance,”Neurosci. Lett.,203, No. 3, 147–150 (1996).
T. H. Bullock, “Signals and signs in the nervous system: the dynamic anatomy of electrical activity is probably information-rich,”Proc. Natl. Acad. Sci. USA,94, No. 1, 1–6 (1997).
M. Fukuda, T. Ono, H. Hishijo, and E. Tabuchi, “Neuronal in monkey anterior putamen during operant barpress behavior,”Brain Res. Bull.,32, No. 3, 227–233 (1993).
T. W. Gardiner, and R. J. Nelson, “Striatal neuronal activity during the initiation and execution of hand movements made in response to visual and vibratory cues,”Exp. Brain. Res.,92, No. 1, 15–26 (1992).
P. M. Gochin, M> Colombo, G. A. Dorfman, G. L. Gerstein, and C. G. Gross, “Neural ensemble coding in inferior temporal cortex,”J. Neurophysiol.,71, No. 6, 2325–2337 (1994).
J. Kruger and F. Aiple, “Multielectrode investigation of monkey striate cortex spike train correlations in the intragranular layers,”J. Neurophysiol.,60, No. 2, 798–828 (1988).
T. I. Lidsky and J. S. Schneider, “Effects of experience on striatal sensory responses,”Neurosci. Lett.,174, No. 2, 141–144 (1994).
P. E. Maldonado and G. L. Gerstein, “Neuronal assembly dynamics in the rat auditory cortex during reorganization induced by intracortical microstimulation,”Exp. Brain Res.,112, No. 3, 431–441 (1996).
H. Nishijo, S. Hattory, K. Makamoto, and T. Oho, “Basal ganglia neural activity during operant feeding behavior in the monkey: relation to sensory integration and motor excution,”Brain Res. Bull.,27, No. 3/4, 463–468 (1991).
C. Ohye, T. Shibazaki, M. Hirato, Y. Kawashima, N. Hayase, A. Takahashi, and K. Watanabe, “Le comportement neuronal du striatum chez l'homme,”Rev. Neurol. Paris,150, No. 8-9, 640–671 (1994).
E. T. Rolls, “Responses of neurons in different regions of striatum of the behaving monkey,” in:The Basal Ganglia: Structure and Function, J. S. McKenzie, et al. (Eds.), New York (1984).
R. Romo, E. Scarnati, and W. Schultz, “Role of primate basal ganglia and frontal cortex in the internal generation of movements. II. Movement-related activity in the anterior striatum,”Exp. Brain Res.,91, No. 3, 385–395 (1992).
R. Romo and W. Schultz, “Role of primate basal ganglia and frontal cortex in the internal generation of movements. III. Neuronal activity in the supplementary,”Exp. Brain Res.,91, No. 3, 396–407 (1992).
W. Schultz and R. Romo, “Role of primate basal ganglia and frontal cortex in the internal generation of movements. I. Preparatory activity in the anterior,”Exp. Brain Res.,91, No. 3, 363–384 (1992).
S. A. Sneider and J. C. Lie,A Stereotaxic Atlas of Monkey Brain (Macaca mulatta). University of Chicago Press, Chicago (1961).
R. P. Travis and D. L. Sparks, “Changes in unit activity during stimuli associated with food and shock reinforcement,”Physiol. Behav.,2, No. 1, 171–178 (1967).
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Translated from Rossiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 8, pp. 705–718, August, 1998.
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Tolkunov, B.F., Orlov, A.A. & Afanas'ev, S.V. Studies of the functional characteristics of central neurons of the brain in a behavioral experiment. Neurosci Behav Physiol 29, 645–656 (1999). https://doi.org/10.1007/BF02462479
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DOI: https://doi.org/10.1007/BF02462479