Summary
The most interesting antagonists of decamethonium iodide known up to now are pentamethonium iodide and tubocurarine. In fact several other compounds principally Paludrine, bis-(2 heptyl)amine and a substituted butylamine are effective inhibitors of the depolarising quaternary ammonium salt in the cat. Stilbamidine, Pentamidine, compound 48–80 and Tween 20 have the same property but are less active. All these compounds have the common property to be histamine liberators.
References
W. D. M. Paton etE. J. Zaimis, Brit. J. Pharmacol.4, 381 (1949).
M. J. Dallemagne etE. Philippot, Brit. J. Pharmacol.7, 601 (1952).
O. F. Hutter etJ. E. Pascoe, Brit. J. Pharmacol.6, 691 (1951).
J. R. Vane, Brit. J. Pharmacol.4, 14 (1949).
E. Philippot, J. Pharm. Belge7, 202 (1952).
R. Charlier, Arch. Int. Pharmacodyn. (sous presse).
E. Philippot etM. J. Dallemagne, Arch. exp. Path. Pharm.220, 100 (1953).
R. Baltzly, J. S. Buck, E. J. de Beer etF. J. Webb, Amer. Chem. Soc.71, 1301 (1949).
J. R. Vane, Brit. J. Pharmacol.4, 14 (1949).
W. Feldberg etW. D. M. Paton, J. Physiol.114, 490 (1951).
F. C. Mac Intosh etW. D. M. Paton, J. Physiol.109, 190 (1949).
W. D. M. Paton, Brit. J. Pharmacol.6, 499 (1951).
J. Lecomte, Arch. intern. Physiol.60, 179 (1952).
W. Feldberg etW. D. M. Paton, J. Physiol.114, 490 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dallemagne, M.J., Philippot, E. Antagonistes de l'iodure de décaméthonium à la jonction neuro-musculaire. Experientia 9, 427–428 (1953). https://doi.org/10.1007/BF02175533
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02175533